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Sigma-Aldrich

Ethyl (4-methylbenzoyl)acetate

Synonym(s):

Ethyl 3-(4-methylphenyl)-3-oxopropanoate, Ethyl 3-oxo-3-(4-tolyl)propionate, NSC 158544

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About This Item

Linear Formula:
CH3C6H4COCH2CO2CH2CH3
CAS Number:
27835-00-3
Molecular Weight:
206.24
MDL number:
MFCD03424815
UNSPSC Code:
12352100
PubChem Substance ID:
24879791
NACRES:
NA.22

refractive index

n20/D 1.5315 (lit.)

bp

244-245 °C (lit.)

density

1.056 g/mL at 25 °C (lit.)

SMILES string

CCOC(=O)CC(=O)c1ccc(C)cc1

InChI

1S/C12H14O3/c1-3-15-12(14)8-11(13)10-6-4-9(2)5-7-10/h4-7H,3,8H2,1-2H3

InChI key

GEQMJBPKCOZHMV-UHFFFAOYSA-N

Application

Ethyl (4-methylbenzoyl)acetate may be used to synthesize 2-(carboethoxy)-3-(4′-methyl)phenylquinoxaline 1,4-dioxide.
Reactant involved in:
  • Oxidative cross-coupling with indoles
  • Electrophilic / nucleophilic halogenation
  • Cyclization with alkynyl ketones
  • Lewis base catalyzed hydrosilylation
  • Stereoselective reduction
  • Intramolecular Michael addition reactions

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Comparative Use of Solvent-free KF-Al2O3 and K2CO3 in Acetone in the Synthesis of Quinoxaline 1, 4-Dioxide Derivatives Designed as Antimalarial Drug Candidates.
Lima LM, et al.
Journal of Heterocyclic Chemistry, 42(7), 1381-1385 (2005)

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