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T7665

Sigma-Aldrich

Tyrphostin 51

≥98%

Synonyme(s) :

2-Amino-1,1,3-tricyano-4-(3′,4′,5′-trihydroxyphenyl)butadiene

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About This Item

Formule empirique (notation de Hill):
C13H8N4O3
Numéro CAS:
126433-07-6
Poids moléculaire :
268.23
Numéro MDL:
MFCD00133903
Code UNSPSC :
12352200
ID de substance PubChem :
24278756
Nomenclature NACRES :
NA.77

Source biologique

synthetic (organic)

Pureté

≥98%

Forme

powder

Puissance

0.8 μM IC50

Solubilité

DMSO: soluble 5 mg of Tyrphostin 51 in 0.1 ml of solvent, clear, orange to red

Température de stockage

2-8°C

Chaîne SMILES 

NC(\C(=C\c1cc(O)c(O)c(O)c1)C#N)=C(/C#N)C#N

InChI

1S/C13H8N4O3/c14-4-8(12(17)9(5-15)6-16)1-7-2-10(18)13(20)11(19)3-7/h1-3,18-20H,17H2/b8-1+

Clé InChI

JKNOYWVMHPMBEL-UNXLUWIOSA-N

Informations sur le gène

human ... CDK2(1017) , EGFR(1956)

Application

Tyrphostin 51 has been used to study the inhibition of rat hepatic leptin 1.

Actions biochimiques/physiologiques

Tyrphostin 51 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.
EGFR tyrosine kinase inhibitor.

Caractéristiques et avantages

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Notes préparatoires

5 mg of Tyrphostin 51 is soluble in 0.1 ml of DMSO and yields a clear, orange to red solution.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Shah M Khan et al.
The Journal of clinical endocrinology and metabolism, 90(1), 469-473 (2004-10-21)
Growth factors may be involved in the control of ovarian cell fate and could contribute to regulation of ovarian cell apoptosis. Our objective is to test the hypothesis that, in human luteinized granulosa cells, epidermal growth factor (EGF) works through
P Yaish et al.
Science (New York, N.Y.), 242(4880), 933-935 (1988-11-11)
A systematic series of low molecular weight protein tyrosine kinase inhibitors were synthesized; they had progressively increasing affinity over a 2500-fold range toward the substrate site of epidermal growth factor (EGF) receptor kinase domain. These compounds inhibited EGF receptor kinase
A Gazit et al.
Journal of medicinal chemistry, 32(10), 2344-2352 (1989-10-01)
A novel class of low molecular weight protein tyrosine kinase inhibitors is described. These compounds constitute a systematic series of molecules with a progressive increase in affinity toward the substrate site of the EGF receptor kinase domain. These competitive inhibitors

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