SML1527

Abiraterone acetate

≥98% (HPLC)

• Synonyme(s) : CB 7598, 17-(Pyridin-3-yl)androsta-5,16-dien-3β-yl acetate
• Formule empirique (notation de Hill): C₂₆H₃₃NO₂
• Numéro CAS: 154229-18-2
• Poids moléculaire : 391.55
• Numéro MDL: MFCD00934213
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825944
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear
• Température de stockage: −20°C
• Chaîne SMILES: C[C@]12C(C[C@@H](OC(C)=O)CC2)=CC[C@]3([H])[C@]1([H])CC[C@@]4(C)[C@@]3([H])CC=C4C5=CC=CN=C5
• InChI: 1S/C26H33NO2/c1-17(28)29-20-10-12-25(2)19(15-20)6-7-21-23-9-8-22(18-5-4-14-27-16-18)26(23,3)13-11-24(21)25/h4-6,8,14,16,20-21,23-24H,7,9-13,15H2,1-3H3/t20-,21-,23-,24-,25-,26+/m0/s1
• Clé InChI: UVIQSJCZCSLXRZ-UBUQANBQSA-N
• Informations sur le gène: human ... CYP17A1(1586)

Description

Application

Abiraterone acetate has been used to study its antitumor action in 3D micro-tumour platform.

Actions biochimiques/physiologiques

Abiraterone acetate is a prodrug of abiraterone, which is a potent, selective, and orally bioavailable inhibitor of CYP17A1 (CYP450c17), an enzyme that catalyzes two key serial reactions (17α hydroxylase and 17,20 lyase) in androgen and estrogen biosynthesis resulting in the formation of DHEA and androstenedione, which may ultimately be metabolized into testosterone. CYP17 is the key enzyme for androgen biosynthesis in both the testes and adrenals, so its inhibition should stop the production of androgens in both places. Abiraterone acetate is used for the treatment of metastatic castration-resistant prostate cancer. Abiraterone acetate possesses significant antitumor activity in post-docetaxel patients with CRPC (castration-resistant prostate cancer). It is highly essential for androgen biosynthesis in the testes, adrenal glands, and prostate tissue.

Informations sur la sécurité

• Pictogrammes: GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H360F,H373,H410
• Conseils de prudence: P202 - P260 - P273 - P280 - P308 + P313 - P391
• Classification des risques: Aquatic Chronic 1 - Repr. 1B - STOT RE 2
• Organes cibles: Endocrine system
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable