SML0569

RO-3306

≥98% (HPLC), powder, CDK1 inhibitor

• Synonyme(s) : (5Z)-5-Quinolin-6-ylmethylene-2-[(thiophen-2-ylmethyl)-amino]-thiazol-4-one, 5-(6-Quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
• Formule empirique (notation de Hill): C₁₈H₁₃N₃OS₂
• Numéro CAS: 872573-93-8
• Poids moléculaire : 351.45
• Numéro MDL: MFCD17392573
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825559
• Nomenclature NACRES : NA.77

Propriétés

• product name: RO-3306, ≥98% (HPLC)
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: off-white to brown
• Solubilité: DMSO: 5 mg/mL, clear
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC4=C(C=C3)N=CC=C4
• InChI: 1S/C18H13N3OS2/c22-17-16(24-18(21-17)20-11-14-4-2-8-23-14)10-12-5-6-15-13(9-12)3-1-7-19-15/h1-10H,11H2,(H,20,21,22)/b16-10-
• Clé InChI: XOLMRFUGOINFDQ-YBEGLDIGSA-N

Description

Application

RO-3306 has been used:

• To study the significance of CA4-mediated cytotoxicity in mitotic arrest
• In cell cycle synchronization to conduct a study on proteomics
• As a CDK1 inhibitor, to prevent early mitotic entry

Actions biochimiques/physiologiques

CDK1 (cyclin dependent kinase 1) is considered to be the “master switch” in cell division, which maintains the mitotic state of cells.

RO-3306 is a selective ATP-competitive inhibitor of CDK1. It inhibites CDK1 cyclin B1 activity with Ki of 35 nM, nearly 10-fold selectivity relative to CDK2/cyclin E and over 50-fold relative to CDK4/cyclin D. RO-3306 has been used to cause cell cycle arrest at the G2/M boundary.

Caractéristiques et avantages

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable