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SAB4200216

Sigma-Aldrich

Monoclonal Anti-Caveolin-1 antibody produced in mouse

enhanced validation

clone CAV1, tissue culture supernatant

Synonyme(s) :

Anti-BSCL3, Anti-CAV1, Anti-CGL3, Anti-MSTP085, Anti-VIP21, Anti-caveolae protein, 22kDa

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About This Item

Numéro MDL:
MFCD01633097
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

tissue culture supernatant

Type de produit anticorps

primary antibodies

Clone

CAV1, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen 22 kDa

Espèces réactives

rat, human, mouse

Validation améliorée

independent
Learn more about Antibody Enhanced Validation

Technique(s)

immunohistochemistry: suitable
indirect immunofluorescence: 1:1000-1:2000 using human HUVEC or mouse 3T3 cells.
western blot: suitable

Isotype

IgM

Numéro d'accès UniProt

Q03135

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CAV1(857)
mouse ... Cav1(12389)
rat ... Cav1(25404)

Description générale

Caveolin-1 (CAV1) is a multifunctional scaffolding protein, that has three exons. It is located on human chromosome 7q31.

Immunogène

synthetic peptide corresponding to a sequence at the N-terminal of human caveolin-1, conjugated to KLH.

Application

Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Monoclonal Anti-Caveolin-1 antibody has been used in western blot analysis.

Actions biochimiques/physiologiques

Caveolin-1 may play a major role in the growth and evolution of cancer. It participates in glucose metabolism. It may also participate in angiogenesis. Cav-1 helps to control the expression of glucose transporters.

Forme physique

Culture supernatant solution containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Réf. du produit
Description
Tarif

Code de la classe de stockage

10 - Combustible liquids

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Expression of flotilin-2 and acrosome biogenesis are regulated by MiR-124 during spermatogenesis
Wu Y, et al.
PLoS ONE, 10(8), e0136671-e0136671 (2015)
Ye Xiong et al.
Oncotarget, 8(15), 24902-24914 (2017-02-18)
As the most prevalent primary brain tumor, gliomas are highly metastatic, invasive and are characteristic of high levels of glial cell-line derived neurotrophic factor (GDNF). GDNF is an important factor for invasive glioma cell growth; however, the underlying mechanism involved
Margaret E Tome et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 38(12), 2209-2222 (2018-10-23)
P-glycoprotein (PgP) is the major drug efflux pump in human cerebral microvessels. PgP prevents pathogens, toxins and therapeutic drugs from entering the CNS. Understanding the molecular regulation of PgP activity will suggest novel mechanisms to improve CNS drug delivery. Previously
Joshua Chuck Harrell et al.
Cancer research, 67(21), 10582-10591 (2007-11-03)
The lymphatic system is a common avenue for the spread of breast cancer cells and dissemination through it occurs at least as frequently as hematogenous metastasis. Approximately 75% of primary breast cancers are estrogen receptor (ER) positive and the majority
Adam C Midgley et al.
The Journal of biological chemistry, 290(18), 11218-11234 (2015-02-27)
Hyaluronan (HA) promotes transforming growth factor (TGF)-β1-driven myofibroblast phenotype. However, HA can also have disease-limiting activity. Bone morphogenetic protein-7 (BMP7) is an antifibrotic cytokine that antagonizes TGF-β1, and isolated studies have demonstrated that HA can both mediate and modulate BMP7
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