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S7900

Sigma-Aldrich

Saponin from quillaja bark

Sapogenin content ≥10 %

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About This Item

Numéro CAS:
8047-15-2
Numéro CE :
232-462-6
Numéro MDL:
MFCD00081981
Code UNSPSC :
12161902
Nomenclature NACRES :
NA.32

Description

non-ionic

Composition

Sapogenin content, ≥10%

Technique(s)

HPLC: suitable
protein quantification: suitable

Cendres sulfatées

<20%

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Description générale

Saponins are natural steroidal glycoside (terpenes).

Application

Saponin from Quillaja bark has been used:
  • to stain CD4+ and CD8+ T-cells
  • to lyse trophozoite-infected red blood cells
  • in immunohistochemical staining

Actions biochimiques/physiologiques

Saponins are associated with many biological and pharmacological activities. It is known to stimulate immune response in mammals. Hence it is used as vaccine adjuvants. Saponins possesses antiviral, antifungal, antitumor, anti-inflammatory, hypoglycemic and hypocholesterolemic effects.
Saponins solubilize the low density lipoprotein (LDL) fraction of cholesterol in micelles, thus lowering their concentration. Saponin from Quillaja bark is used as a flavoring agent in food and beverages. This saponin has been shown to enhance immune-cell proliferation in vitro.
Potent hemolytic when injected i.v.; surfactant that enhances penetration of proteins and other macromolecules through cell membranes; it also has been used as an adjuvant for vaccines.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H319,H335

Classification des risques

Eye Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Joo Young Park et al.
Journal of hazardous materials, 163(2-3), 761-767 (2008-08-12)
The applicability of microbubble suspension made of saponin as a biodegradation-enhancing carrier where oxygen and pollutant-degraders are limited was studied. The saponin-microbubble suspension was used to deliver phenanthrene-degrading bacteria, inorganic nutrients, and oxygen. Bench-scale study was carried out to determine
Samantha Reiss et al.
PloS one, 12(10), e0186998-e0186998 (2017-10-25)
The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in tissues, is key for a broad range of immunological research, including vaccine responses and infectious diseases. Detection of these cells is hampered by both their
Natalie J Spillman et al.
Molecular and biochemical parasitology, 162(1), 96-99 (2008-08-05)
The intraerythrocytic malaria parasite, Plasmodium falciparum maintains an intracellular pH (pH(i)) of around 7.3. If subjected to an experimentally imposed acidification the parasite extrudes H(+), thereby undergoing a pH(i) recovery. In a recent study, Bennett et al. [Bennett TN, Patel
Induction of human papillomavirus-specific CD4(+) and CD8(+) lymphocytes by E7-pulsed autologous dendritic cells in patients with human papillomavirus type 16- and 18-positive cervical cancer.
Santin AD
Journal of Virology, 73(7), 5402-5410 (1999)
Metabolite profiling of the intraerythrocytic malaria parasite Plasmodium falciparum by (1)H NMR spectroscopy.
Teng R
Nmr in Biomedicine, 22(3), 292-302 (2009)
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