Accéder au contenu
Merck
Toutes les photos(3)

Key Documents

View All Documentation

P7762

Sigma-Aldrich

Poly-L-arginine hydrochloride

mol wt 15,000-70,000

Synonyme(s) :

L-Arginine homopolymer hydrochloride

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme
Toutes les photos(3)

About This Item

Numéro CAS:
26982-20-7
Numéro MDL:
MFCD00166393
Code UNSPSC :
12352209
ID de substance PubChem :
24898874
Nomenclature NACRES :
NA.26

Forme

powder

Poids mol.

15,000-70,000

Couleur

white to off-white

Application(s)

cell analysis

Température de stockage

−20°C

Chaîne SMILES 

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

Clé InChI

PQEISBBDIRAKGR-LFELFHSZSA-N

Vous recherchez des produits similaires ? Visite Guide de comparaison des produits

Catégories apparentées

Description générale

Poly-L-arginine hydrochloride (PLA) is a homopolyamino acid. PLA enhances membrane permeability compared to poly-L-lysine. It has applications as drug carrier, neuroprotective agent and in anticancer vaccines preparations. Peptide vaccines in conjugation with PLA promotes antigen-presenting cells (APCs) to generate T cell and elicit immunostimulant functionality.

Application

Poly-L-arginine hydrochloride has been used:
  • to generate complex with stimulatory RNA isRNA9.2 as in neutrophils
  • used in ribosomal RNA transfection into human monocytic THP-1 cells
  • for coating alginate capsule beads

Qualité

Contains 3% or less ornithine residue.

Remarque sur l'analyse

Molecular weight based on viscosity of precursor poly-L-ornithine. Also assayed by MALLS.

Autres remarques

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

RNA of Enterococcus faecalis strain EC-12 is a major component inducing interleukin-12 production from human monocytic cells
Nishibayashi R, et al.
PLoS ONE, 10(6), e0129806-e0129806 (2015)
Neutrophils express distinct RNA receptors in a non-canonical way
Berger M, et al.
The Journal of Biological Chemistry, 287(23), 19409-19417 (2012)
Kotaro Sakamoto et al.
Frontiers in pharmacology, 12, 751587-751587 (2021-11-26)
Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established. Vasoactive intestinal peptide receptor 2 (VIPR2) might be an attractive drug target for the treatment of schizophrenia because both preclinical and
Antibacterial activity of poly-l-arginine under different conditions
Sepahi M , et al.
Iranian Journal of Microbiology, 9(2), 103-103 (2017)
Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells
Bhujbal SV, et al.
Journal of the Mechanical Behavior of Biomedical Materials, 37, 196-208 (2014)
Afficher tous les articles scientifiques apparentés

Articles

Layer-by-Layer (LbL) Assembly, A "Gentle Yet Flexible" Method Toward Functional Biomaterials

Recently, layer-by-layer (LbL) assembly has emerged as a versatile, gentle and, simple method for immobilization of functional molecules in an easily controllable thin film morphology.1,2 In this short review, we introduce recent advances in functional systems fabricated by using the mild, yet adaptable LbL technique.

Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique