P4235

Anti-p53 antibody produced in sheep

fractionated antiserum, buffered aqueous solution

• Numéro MDL: MFCD00164709
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: sheep
• Niveau de qualité: 200
• Conjugué: unconjugated
• Forme d'anticorps: fractionated antiserum
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Forme: buffered aqueous solution
• Poids mol.: antigen 53 kDa
• Espèces réactives: rat, mouse, human
• Technique(s): immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable; immunoprecipitation (IP): suitable; western blot: 1-10 μg/mL
• Numéro d'accès UniProt: P04637
• Conditions d'expédition: dry ice
• Température de stockage: −20°C
• Informations sur le gène: human ... TP53(7157) ; mouse ... Trp53(22059) ; rat ... Tp53(24842)

Description

Description générale

p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.

Immunogène

GST fusion protein of human p53 corresponding to amino acids 1-393.

Application

Monoclonal Anti-p53-Biotin antibody produced in mouse has been used for Western Blotting.

Actions biochimiques/physiologiques

Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.

Forme physique

Solution in 0.01 M phosphate buffered saline, containing 0.08% sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable