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N6413

Sigma-Aldrich

Anti-NR4A2 (N-terminal) antibody produced in rabbit

~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution

Synonyme(s) :

Anti-HZF-3, Anti-NOT, Anti-NURR1, Anti-RNR1, Anti-TINUR

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Poids mol.

~70 kDa

Espèces réactives

human, mouse, rat

Concentration

~1.5 mg/mL

Technique(s)

indirect immunofluorescence: 4-8 μg/mL using 3T3 cells
western blot: 1-2 μg/mL using HEK-293T cell lysate expressing human NR4A2

Numéro d'accès UniProt

P43354

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... NR4A2(4929)
mouse ... Nr4a2(18227)
rat ... Nr4a2(54278)

Catégories apparentées

Description générale

Nuclear receptor subfamily 4 group A member 2 (NR4A2) is part of transcriptional regulator subfamily, under the family of nuclear hormone receptors. It is a transcription factor expressed in the brain and T-cells.

Application

Anti-NR4A2 (N-terminal) antibody has been used in
  • immunoblotting
  • immunofluorescence
  • western blotting

Actions biochimiques/physiologiques

NR4A2 binds the NGFI-B (nerve growth factor-induced clone B) response element (NBRE) sequence (AAAGGTCA) as monomer. NR4A2 is induced by multiple extracellular signals, including fatty acids, stress, growth factors and neurotransmitters in a cell type specific manner. Hepatic expression of NR4A2 is induced by cAMP in response to glucagon and fasting. NR4A2 is essential for the differentiation of nigral dopaminergic neurons. NR4A2 mutations have been associated with disorders related to dopaminergic dysfunction, including Parkinson′s disease, schizophrenia.
Nuclear receptor subfamily 4 group A member 2 (NR4A2) acts as an activator of tyrosine hydroxylase. It is crucial for the process of DNA repair by melanocortin-1 receptor.

Description de la cible

NR4A2 (N-terminal) encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, includ

Forme physique

Solution in 0.01 M phos­phate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Huimin Gao et al.
Scientific reports, 6, 34403-34403 (2016-09-30)
The nuclear orphan receptor, Nur77 plays important roles in neuroimflammation, apoptosis, and dopaminergic neurodegeneration. We conducted a further mechanistic investigation into the association of Nur77 with cell death. Cytosporone B (Csn-B), an agonist for Nur77, and Nur77 knockdown were adopted
Minireview: Nuclear hormone receptor 4A signaling: implications for metabolic disease
Pearen M A and Muscat G E
Molecular Endocrinology, 24(10), 1891-1903 (2010)
Optogenetic inhibitor of the transcription factor CREB
Ali A M, et al.
Chemistry & Biology, 22(11), 1531-1539 (2015)
Ahmed M Ali et al.
Chemistry & biology, 22(11), 1531-1539 (2015-11-23)
Current approaches for optogenetic control of transcription do not mimic the activity of endogenous transcription factors, which act at numerous sites in the genome in a complex interplay with other factors. Optogenetic control of dominant negative versions of endogenous transcription
Enhancing beta-catenin activity via GSK3beta inhibition protects PC12 cells against rotenone toxicity through Nurr1 induction
Zhang L, et al.
PLoS ONE, 11(4), e0152931-e0152931 (2016)
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