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Key Documents

N1638

Sigma-Aldrich

Nystatin Suspension

suspension, non-animal origin, suitable for cell culture, BioReagent

Synonyme(s) :

Fungicidin, Mycostatin

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About This Item

Numéro CAS:
Code UNSPSC :
12352207
ID de substance PubChem :
Nomenclature NACRES :
NA.76

product name

Nystatin Suspension, suspension, 10,000 unit/mL in DPBS, BioReagent, suitable for cell culture

Gamme de produits

BioReagent

Niveau de qualité

Forme

suspension

Concentration

10,000 unit/mL in DPBS

Technique(s)

cell culture | mammalian: suitable

Impuretés

endotoxin, tested

Couleur

yellow

Spectre d'activité de l'antibiotique

fungi
yeast

Mode d’action

cell membrane | interferes

Conditions d'expédition

dry ice

Température de stockage

−20°C

Chaîne SMILES 

C[C@@H]1OC(=O)C[C@H](O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C[C@@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@H](N)[C@@H]3O)\C=C\C=C\C=C\C=C\CC\C=C\C=C\[C@H](C)[C@@H](O)[C@@H]1C)O2)C(O)=O

InChI

1S/C47H75NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-36(53)35(52)20-19-31(49)21-32(50)22-33(51)23-39(55)62-29(3)28(2)42(27)56/h5-6,8,10-18,27-38,40-44,46,49-54,56-58,61H,7,9,19-26,48H2,1-4H3,(H,59,60)/b6-5+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28+,29-,30+,31+,32+,33+,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

Clé InChI

VQOXZBDYSJBXMA-QEKUPDCNSA-N

Description générale

Chemical structure: polyene

Application

Nystatin suspension has been used:
  • to inhibit caveolin-mediated endocytosis
  • as a component of Eagle′s minimum essential medium (EMEM)
  • to enumerate lactic acid bacteria (LAB)
  • in preventing cell culture contamination and inducing interleukin (IL)-1, IL-8, and tumor necrosis factor a secretion in toll-like receptor 2 (TLR2)-expressing THP1 cells.
This product is recommended for use in cell culture applications at 24 mL/L.

Actions biochimiques/physiologiques

Nystatin is a polyene, broad-spectrum antibiotic, which modifies the microstructure of lipid rafts. It can sequester cholesterol present on the cell membrane of eukaryotes. Nystatin regulates immune responses through cytokine signaling, lymphocyte activation and pathogen recognition.

Attention

This product is stable at 37°C for three days.

Notes préparatoires

It is 0.1μ filtered and cell culture tested.

Autres remarques

Nystatin suspension available in 20 mL and 100 mL pack size.
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

A method to maintain mammalian cells for days alive at 4 C
Moce-Llivina L and Jofre J
Cytotechnology, 46(1), 57-61 (2004)
Liu He et al.
eLife, 9 (2020-04-16)
The development of a polarized neuron relies on the selective transport of proteins to axons and dendrites. Although it is well known that the microtubule cytoskeleton has a central role in establishing neuronal polarity, how its specific organization is established
Conservation characteristics of corn ears and stover ensiled with the addition of Lactobacillus plantarum MTD-1, Lactobacillus plantarum 30114, or Lactobacillus buchneri 11A44
Lynch JP, et al.
Journal of Dairy Science, 95(4), 2070-2080 (2012)
Ian T Stancil et al.
Nature communications, 12(1), 4566-4566 (2021-07-29)
The airway epithelium serves as the interface between the host and external environment. In many chronic lung diseases, the airway is the site of substantial remodeling after injury. While, idiopathic pulmonary fibrosis (IPF) has traditionally been considered a disease of
Nystatin enhances the immune response against Candida albicans and protects the ultrastructure of the vaginal epithelium in a rat model of vulvovaginal candidiasis
Zhang X, et al.
BMC Microbiology, 18(1), 166-166 (2018)

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