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Key Documents

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M3199

Sigma-Aldrich

MK-212 hydrochloride

≥98% (HPLC)

Synonyme(s) :

2-Chloro-6-(1-piperazinyl)-pyrazine hydrochloride, 6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride, NSC 31732

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About This Item

Formule empirique (notation de Hill):
C8H11ClN4·HCl
Numéro CAS:
61655-58-1
Poids moléculaire :
235.11
Numéro CE :
262-883-0
Numéro MDL:
MFCD00673963
Code UNSPSC :
12352200
ID de substance PubChem :
329817966
Nomenclature NACRES :
NA.77

Pureté

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

white to off-white

Solubilité

DMSO: ≥20 mg/mL

Température de stockage

2-8°C

Chaîne SMILES 

Cl.Clc1cncc(n1)N2CCNCC2

InChI

1S/C8H11ClN4.ClH/c9-7-5-11-6-8(12-7)13-3-1-10-2-4-13;/h5-6,10H,1-4H2;1H

Clé InChI

PFIZGLUIYAZQFU-UHFFFAOYSA-N

Actions biochimiques/physiologiques

Selective 5-HT2C serotonin receptor agonist.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H301

Classification des risques

Acute Tox. 3 Oral

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Adriane M dela Cruz et al.
Behavioural pharmacology, 20(8), 720-730 (2009-11-11)
Only a subgroup of human drug users progress from initial drug taking to drug addiction. The learned associations between the effects of the drug and the environment in which it is experienced is an important aspect of the progression to
M L Pierce et al.
Neuroscience, 170(3), 827-838 (2010-07-24)
Neuronal networks generating rhythmic activity as an emergent property are common throughout the nervous system. Some are responsible for rhythmic behaviours, as is the case for the spinal cord locomotor networks; however, for others the function is more subtle and
Martilias Farrell et al.
Psychopharmacology, 211(2), 149-159 (2010-06-08)
The extended ternary complex theory of receptor function states a ligand can be classified as an inverse agonist, agonist, or neutral antagonist based on its ability to preferentially stabilize the inactive conformation, the active conformation, or to have no preference
Nathan S Pentkowski et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 35(10), 2037-2048 (2010-06-04)
Serotonin 2C receptor (5-HT(2C)R) agonists administered systemically attenuate both cocaine-primed and cue-elicited reinstatement of extinguished cocaine-seeking behavior. To further elucidate the function of these receptors in addiction-like processes, this study examined the effects of microinfusing the 5-HT(2C)R agonist MK212 (0
Janet L Neisewander et al.
Behavioural pharmacology, 18(8), 791-800 (2007-11-09)
The extinction/reinstatement model has been used in this study to examine the role of 5-HT2C receptors in cocaine-seeking behavior elicited by cocaine-associated cues and cocaine-priming injections. Rats that had been trained to press a lever for cocaine (0.75 mg/kg/0.1 ml
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