M1523

Muscimol

≥98% (TLC), powder, GABAA receptor agonist.

• Synonyme(s) : 3-Hydroxy-5-aminomethyl-isoxazole, 5-Aminomethyl-3-hydroxy-isoxazole, 5-Aminomethyl-3-isoxazolol, Agarine, Pantherine
• Formule empirique (notation de Hill): C₄H₆N₂O₂
• Numéro CAS: 2763-96-4
• Poids moléculaire : 114.10
• Numéro Beilstein : 1618960
• Numéro CE : 220-430-4
• Numéro MDL: MFCD00057894
• Code UNSPSC : 12352200
• ID de substance PubChem : 24896662
• Nomenclature NACRES : NA.77

Propriétés

• product name: Muscimol, powder
• Forme: powder
• Niveau de qualité: 200
• Couleur: white to off-white
• Température de stockage: 2-8°C
• Chaîne SMILES: NCC1=CC(=O)NO1
• InChI: 1S/C4H6N2O2/c5-2-3-1-4(7)6-8-3/h1H,2,5H2,(H,6,7)
• Clé InChI: ZJQHPWUVQPJPQT-UHFFFAOYSA-N
• Informations sur le gène: rat ... Gabra2(29706)

Description

Description générale

Muscimol is a psychoactive isoxazole component, which is found in Amanita muscaria and related mushrooms. It lowers cerebral glucose metabolism and increases the level of 5-hydroxytryptamine in brain. Muscimol has hallucinogenic effects. It is associated with distorted perceptions, nausea and vomiting.

Application

Muscimol has been used:

• to reduce conditioned fear-expression in lateral amygdala (LA)
• to eliminate cortical cell response in ferrets
• to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in zebra finches

Actions biochimiques/physiologiques

GABA_A receptor agonist.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GABAA Receptors and GABAC Receptors pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300,H336
• Conseils de prudence: P261 - P264 - P271 - P301 + P310 - P304 + P340 + P312 - P403 + P233
• Classification des risques: Acute Tox. 2 Oral - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges