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Merck
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Key Documents

LO4200

Sigma-Aldrich

LOPAC®1280 - Small Scale

International Version

Synonyme(s) :

Library of Pharmacologically Active Compounds - small scale

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About This Item

Numéro CE :
200-664-3
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Forme

liquid

Conditions d'expédition

dry ice

Température de stockage

−20°C

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Description générale

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).

Application

Library of pharmacologically active compounds LOPAC®1280 - small scale has been used to screen for the suppressors of niclosamide- and nigericin-induced interleukin (IL-1β) release.

Caractéristiques et avantages

Includes the latest, drug-like molecules in the fields of Cell Signaling & Neuroscience:

  • Apoptosis
  • G Proteins & Cyclic Nucleotides
  • Gene Regulation & Expression
  • Ion Channels
  • Lipid Signaling
  • Multi-Drug Resistance
  • Neurotransmission
  • Phosphorylation
SDFile provided to construct a database containing:
  • Structure
  • Primary Name
  • Secondary Name
  • Pharmacological Activity
  • Product Number
  • Rack Position

Autres remarques

For sale outside of the U.S. only. U.S. customers should refer to Product Code LO4100.

Informations légales

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Point d'éclair (°F)

188.6 °F

Point d'éclair (°C)

87 °C

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Laura M Alcântara et al.
Molecules (Basel, Switzerland), 25(11) (2020-06-04)
High genetic and phenotypic variability between Leishmania species and strains within species make the development of broad-spectrum antileishmanial drugs challenging. Thus, screening panels consisting of several diverse Leishmania species can be useful in enabling compound prioritization based on their spectrum
Anzar Asad et al.
Basic & clinical pharmacology & toxicology, 133(4), 364-377 (2023-07-03)
Adhesion G protein-coupled receptors (GPCRs) are an underrepresented class of GPCRs in drug discovery. We previously developed an in vivo drug screening pipeline to identify compounds with agonist activity for Adgrg6 (Gpr126), an adhesion GPCR required for myelination of the
Niclosamide activates the NLRP3 inflammasome by intracellular acidification and mitochondrial inhibition
Tran UT and Kitami T
Communications biology, 2(1), 2-2 (2019)
High-throughput screening identifies compounds that enhance lentiviral transduction.
Johnston JM, Denning G, Moot R, et al.
Gene Therapy, doi:10-doi:10 (2014)
Eleanor Star et al.
Oncogenesis, 10(5), 36-36 (2021-05-05)
Alternative splicing of the vascular endothelial growth factor A (VEGF-A) terminal exon generates two protein families with differing functions. Pro-angiogenic VEGF-Axxxa isoforms are produced via selection of the proximal 3' splice site of the terminal exon. Use of an alternative
Afficher tous les articles scientifiques apparentés

Articles

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

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