I8898

Ivermectin

• Synonyme(s) : 22,23-Dihydroavermectin B1, MK-933
• Numéro CAS: 70288-86-7
• Numéro MDL: MFCD00869511
• Code UNSPSC : 12352200
• ID de substance PubChem : 24278497
• Nomenclature NACRES : NA.77

Propriétés

• Forme: powder
• Solubilité: MEK: 50 mg/mL
• Spectre d'activité de l'antibiotique: parasites
• Application(s): agriculture; environmental
• Mode d’action: cell membrane | interferes
• Auteur: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Température de stockage: 2-8°C
• Chaîne SMILES: [H][C@@]1(O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(C)\[C@@H](O[C@H]4C[C@H](OC)[C@@H](O[C@H]5C[C@H](OC)[C@@H](O)[C@H](C)O5)[C@H](C)O4)[C@@H](C)\C=C\C=C6/CO[C@]7([H])[C@H](O)C(C)=C[C@@H](C(=O)O3)[C@]67O)O2)[C@@H](C)CC
• InChI: 1S/C48H74O14/c1-11-25(2)43-28(5)17-18-47(62-43)23-34-20-33(61-47)16-15-27(4)42(26(3)13-12-14-32-24-55-45-40(49)29(6)19-35(46(51)58-34)48(32,45)52)59-39-22-37(54-10)44(31(8)57-39)60-38-21-36(53-9)41(50)30(7)56-38/h12-15,19,25-26,28,30-31,33-45,49-50,52H,11,16-18,20-24H2,1-10H3/b13-12+,27-15+,32-14+/t25-,26-,28-,30-,31-,33+,34-,35-,36-,37-,38-,39-,40+,41-,42-,43+,44-,45+,47+,48+/m0/s1
• Clé InChI: AZSNMRSAGSSBNP-XPNPUAGNSA-N
• Informations sur le gène: human ... ABCB1(5243) , CYP3A4(1576) ; mouse ... Abcb1a(18671) , Abcb1b(18669)

Description

Description générale

Ivermectin is a macro-cyclic lactone, derived from avermectin. It functions as an antiparasitic agent. Ivermectin is used against gastrointestinal roundworms, lungworms, mites and lice. It is used to treat onchocerciasis, strongyloidiasis, ascariasis and filariases.

Application

Ivermectin has been used:

• in Caenorhabditis elegans fecundity assay
• in larval development test
• to measure in vivo topical acaricide activity of compounds in rats
• to assess its acute and chronic effects to zebrafish
• in percutaneous drug injection method to treat cystic echinococcosis
• in liquid chromatography with fluorescence detection method

Actions biochimiques/physiologiques

Positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptor; also modulates glutamate-GABA-activated chloride channels.

Caractéristiques et avantages

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Autres remarques

Primarily ivermectin B_1a.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS08,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H300,H311,H351,H360D,H410
• Conseils de prudence: P202 - P264 - P273 - P280 - P301 + P310 - P302 + P352 + P312
• Classification des risques: Acute Tox. 1 Oral - Acute Tox. 3 Dermal - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1B
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges