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Key Documents

HPA001473

Sigma-Aldrich

Anti-CASP9 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonyme(s) :

Anti-APAF-3 antibody produced in rabbit, Anti-Apoptotic protease Mch-6 antibody produced in rabbit, Anti-Apoptotic protease-activating factor 3 antibody produced in rabbit, Anti-CASP-9 antibody produced in rabbit, Anti-Caspase-9 precursor antibody produced in rabbit, Anti-ICE-LAP6 antibody produced in rabbit, Anti-ICE-like apoptotic protease 6 antibody produced in rabbit

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About This Item

Numéro MDL:
MFCD01864176
Code UNSPSC :
12352203
Numéro HPA (Human Protein Atlas):
HPA001473
Nomenclature NACRES :
NA.43

Source biologique

rabbit

Conjugué

unconjugated

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

primary antibodies

Clone

polyclonal

Gamme de produits

Prestige Antibodies® Powered by Atlas Antibodies

Forme

buffered aqueous glycerol solution

Espèces réactives

mouse, human, rat

Technique(s)

immunoblotting: 0.04-0.4 μg/mL
immunofluorescence: 0.25-2 μg/mL
immunohistochemistry: 1:50-1:200

Séquence immunogène

ALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCEKLRRRFSSLHFMVEVKGDLTAKKMVLALLELAQQDHGALDCCVVVILSHGCQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSC

Numéro d'accès UniProt

P55211

Conditions d'expédition

wet ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... CASP9(842)

Catégories apparentées

Description générale

CASP9 (Caspase-9) gene encodes a protein belonging to the cysteine-aspartic acid protease (caspase) family. It consists of two domains. The large subunit of caspase 9 possesses a seven-residue loop at the C terminal end. The loop helps to interact across the dimer interface.

Immunogène

Caspase-9 precursor recombinant protein epitope signature tag (PrEST)

Application

Anti-CASP9 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Actions biochimiques/physiologiques

CASP9 (Caspase-9) is involved in the apoptotic pathway. The caspases exist as inactive proenzymes that are activated upon proteolytic processing at conserved aspartic residues. The active enzyme is a dimer of one small and one large subunit. It functions as an initiator caspase that is activated by mitochondrial-mediated apoptotic pathway. It executes apoptosis by activating a cascade of effector caspases. It also acts as a tumor suppressor.

Caractéristiques et avantages

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Liaison

Corresponding Antigen APREST79896

Forme physique

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Informations légales

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 1

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

M S Soengas et al.
Science (New York, N.Y.), 284(5411), 156-159 (1999-04-02)
The ability of p53 to promote apoptosis in response to mitogenic oncogenes appears to be critical for its tumor suppressor function. Caspase-9 and its cofactor Apaf-1 were found to be essential downstream components of p53 in Myc-induced apoptosis. Like p53
The intrinsic or the extrinsic pathways of apoptosis in the epidermis after cladribine application?
Wrzos PC, et al.
Journal of Biomedical Science and Engineering, 6 (2013)
Michelle M Hill et al.
Molecular interventions, 3(1), 19-26 (2004-03-03)
Apoptosis (programmed cell death) is a physiological process used to eliminate superfluous, damaged, infected, or aged cells in multicellular organisms. During apoptosis the cellular architecture is dismantled from within in a highly controlled fashion. Members of the caspase family of
Anuradha Cingeetham et al.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 35(9), 8813-8822 (2014-06-01)
Abnormal apoptosis is one of the hallmarks of cancers including acute myeloid leukemia (AML), as it plays a pivotal role in precisely maintaining self-renewal, proliferation, and differentiation properties of hematopoietic stem cells (HSCs). Caspase9 (CASP9), an initiator caspase activated by
Michael W Ronellenfitsch et al.
Brain pathology (Zurich, Switzerland), 28(1), 94-102 (2016-12-10)
We report a novel CASP9 germline mutation that may increase susceptibility to the development of brain tumors. We identified this mutation in a family in which three brain tumors had developed within three generations, including two anaplastic astrocytomas occurring in
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