H4381

6-Hydroxydopamine hydrochloride

≥97% (titration), powder, neurotoxin

• Synonyme(s) : 2,4,5-Trihydroxyphenethylamine hydrochloride, 2,5-Dihydroxytyramine hydrochloride, 2-(2,4,5-Trihydroxyphenyl)ethylamine hydrochloride, 6-OHDA
• Formule linéaire : (HO)₃C₆H₂CH₂CH₂NH₂ · HCl
• Numéro CAS: 28094-15-7
• Poids moléculaire : 205.64
• Numéro Beilstein : 4274007
• Numéro CE : 248-837-2
• Numéro MDL: MFCD00012895
• Code UNSPSC : 12352116
• ID de substance PubChem : 24895641
• Nomenclature NACRES : NA.77

Propriétés

• product name: 6-Hydroxydopamine hydrochloride, ≥97% (titration), powder
• Pureté: ≥97% (titration)
• Forme: powder
• Couleur: off-white to brown
• Pf: 232-233 °C (dec.) (lit.)
• Solubilité: H₂O: >50 mg/mL, clear, yellow to brown
• Température de stockage: room temp
• Chaîne SMILES: Cl.NCCc1cc(O)c(O)cc1O
• InChI: 1S/C8H11NO3.ClH/c9-2-1-5-3-7(11)8(12)4-6(5)10;/h3-4,10-12H,1-2,9H2;1H
• Clé InChI: QLMRJHFAGVFUAC-UHFFFAOYSA-N

Description

Description générale

6-Hydroxydopamine hydrochloride (6-OHDA) is a neurotoxin, commonly used to induce Parkinson′s disease (PD). 6-OHDA causes death of dopaminergic neurons in substantia nigra pars compacta progressively mimicking PD. 6-OHDA is highly oxidizable and cannot cross blood brain barrier. 6-OHDA exerts cytotoxicity by generating reactive oxygen species, initiating cellular stress and cell death. 6-OHDA leads to neuronal cell death in many in vitro models like primary neuronal culture, human neuroblastoma cell line and rat adrenal pheochromocytoma cell line, PC12.

Application

6-hydroxydopamine hydrochloride has been used:

• to induce Parkinson′s disease (PD) in rats
• to analyse cytotoxic effect of 6-OHDA on PC12 cell line
• to induce noradrenergic (NA) neuron deletion from the locus-coeruleus

Actions biochimiques/physiologiques

Neurotoxin that destroys catecholaminergic terminals.

Attention

Hygroscopic

Reconstitution

Dissolve in oxygen-free water containing 0.1% sodium metabisulfite or other antioxidants.

Solutions should be freshly prepared and protected from exposure to light. Solutions turn red as it oxidizes.

Autres remarques

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves