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G9910

Sigma-Aldrich

Sodium glycodeoxycholate

BioXtra, ≥97% (HPLC)

Synonyme(s) :

3α,12α-Dihydroxy-5β-cholan-24-oic acid N-(carboxymethyl)amide, Glycodeoxycholic acid sodium salt, Glycodesoxycholic acid, N-(3α,12α-Dihydroxy-24-oxocholan-24-yl)glycine

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About This Item

Formule empirique (notation de Hill):
C26H42NNaO5
Numéro CAS:
16409-34-0
Poids moléculaire :
471.61
Numéro CE :
240-455-4
Numéro MDL:
MFCD00036742
Code UNSPSC :
12161900
ID de substance PubChem :
24895386
Nomenclature NACRES :
NA.25

Description

anionic

Gamme de produits

BioXtra

Pureté

≥97% (HPLC)

Poids mol.

471.61 g/mol

Impuretés

≤0.0025% Phosphorus (P)
≤0.1% Insoluble matter

CMC

2.1 mM

Solubilité

H2O: 0.1 M, clear to slightly hazy, colorless to almost colorless

Traces d'anions

chloride (Cl-): ≤1%
sulfate (SO42-): ≤0.05%

Traces de cations

Al: ≤0.0005%
Ca: ≤0.011%
Cu: ≤0.0005%
Fe: ≤0.001%
K: ≤0.005%
NH4+: ≤0.05%
Pb: ≤0.001%
Zn: ≤0.003%

Chaîne SMILES 

[Na].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@]([H])([C@H](C)CCC(=O)NCC(O)=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C26H43NO5.Na.H/c1-15(4-9-23(30)27-14-24(31)32)19-7-8-20-18-6-5-16-12-17(28)10-11-25(16,2)21(18)13-22(29)26(19,20)3;;/h15-22,28-29H,4-14H2,1-3H3,(H,27,30)(H,31,32);;/t15-,16-,17-,18+,19-,20+,21+,22+,25+,26-;;/m1../s1

Clé InChI

BMYWWGPEKRLDGW-ZXMGEDLUSA-N

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Description générale

Sodium glycodeoxycholate is a bile salt that can be used to form biomimicking environments.

Application

Sodium glycodeoxycholate has been used in a study to develop more similar mimetic intestinal fluids to physiological fluids than those developed by mixed bile salt systems (MBS). It has also been used in a study to investigate Ca2+ buffering capability of bile salt micelles.

Actions biochimiques/physiologiques

Induces apoptosis in hepatocytes; may induce DNA cleavage.

Autres remarques

Bile Salt

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Hu-He Chen et al.
Guang pu xue yu guang pu fen xi = Guang pu, 30(3), 748-752 (2010-05-26)
In the present article, NaGDC was used to study the Ca(2+)-buffering capability of bile salt micelles. NaGDC is a naturally occurring bile salt which constitutes approximately 10 molar percent of bile salt composition in gallbladder. The authors selected glycine conjugated
Bile salt composition is secondary to bile salt concentration in determining hydrocortisone and progesterone solubility in intestinal mimetic fluids
Huda H Zughaid, et al.
International Journal of Pharmaceutics, 422, 7-7 (2012)
Raina Thakur et al.
Photochemistry and photobiology, 88(5), 1248-1255 (2012-05-23)
Photophysical properties of two widely used antibiotic fluoroquinolone drugs, namely Norfloxacin (NOR) and Ofloxacin (OFL) have been investigated in biomimicking environments formed by bile salts. Experimental results demonstrate that photophysical enhancement and fall of a particular prototropic species are sensitive
Domenico Trombetta et al.
Nutrients, 12(11) (2020-11-11)
Almond kernels contain phytochemicals with positive health effects in relation to heart disease, diabetes and obesity. Several studies have previously highlighted that almond cell wall encapsulation during digestion and particle size are factors associated with these benefits. In the present
Elisabetta De Angelis et al.
Food & function, 8(4), 1599-1610 (2017-03-16)
Soy is an important component of the human diet thanks to its nutritional value and high protein content; however, it also represents a risk for allergenic consumers due to its potential to trigger adverse reactions in sensitized individuals. The putative
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