F8307

FR-900098 monosodium salt

≥97% (NMR)

• Synonyme(s) : (3-(Acetylhydroxyamino)propyl)-phosphonic acid, BRN 2096083, P-[3-(Acetylhydroxyamino)propyl]-phosphonic acid
• Formule empirique (notation de Hill): C₅H₁₁NNaO₅P
• Numéro CAS: 73226-73-0
• Poids moléculaire : 219.11
• Numéro MDL: MFCD17215926
• Code UNSPSC : 51111800
• ID de substance PubChem : 329799770
• Nomenclature NACRES : NA.77

Propriétés

• Pureté: ≥97% (NMR)
• Forme: powder
• Conditions de stockage: desiccated; protect from light
• Couleur: white to light brown
• Solubilité: H₂O: ≥20 mg/mL
• Température de stockage: −20°C
• Chaîne SMILES: [Na+].CC(=O)N(O)CCCP(O)([O-])=O
• InChI: 1S/C5H12NO5P.Na/c1-5(7)6(8)3-2-4-12(9,10)11;/h8H,2-4H2,1H3,(H2,9,10,11);/q;+1/p-1
• Clé InChI: LCFXFDGYDKNWMD-UHFFFAOYSA-M

Description

Actions biochimiques/physiologiques

1-deoxy-D-xylulose 5-phosphate reductoisomerase (DXR) is an enzyme involved in the first step in the nonmevalonate pathway for isoprenoid biosynthesis in Gram-negative, Gram-positive bacteria, plants, and the parasite causing the most virulent form of malaria, Plasmodium falciparum (Mammals produce isoprenoids via the mevalonate pathway). Inhibiton of the enzyme provides alternative to traditional antimalaria therapy. FR-900098 is twice more effective than fosmidomycin against various strains of P. falciparum in vitro and the closely related P. vinckei in mice.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable