This product is tested in absolute ethanol at a concentration of 50 mg/mL. The stability of the solution at 4°C has not been evaluated. When stored at -20°C, the solution should be kept in aliquots to prevent repetitive freeze/thaw cycles.
E8875
17β-Estradiol
≥98% (HPLC), powder, estrogenic hormone
Synonyme(s) :
1,3,5-Estratriene-3,17β-diol, 17β-Estradiol, 3,17β-Dihydroxy-1,3,5(10)-estratriene, Dihydrofolliculin
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| Conditionnement | Référence | Disponibilité | Prix |
|---|
A propos de cet article
Formule empirique (notation de Hill) :
C18H24O2
Numéro CAS:
Poids moléculaire :
272.38
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352104
EC Number:
200-023-8
MDL number:
Beilstein/REAXYS Number:
1914275
Le tarif et la disponibilité ne sont pas disponibles actuellement.
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Laissez-nous vous aiderNom du produit
β-Estradiol, ≥98%
biological source
synthetic (organic)
Quality Level
sterility
non-sterile
assay
≥98%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
176-180 °C (lit.)
solubility
ethanol: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
SMILES string
O[C@H]1CC[C@@]2([H])[C@]3([H])CCC4=CC(O)=CC=C4[C@@]3([H])CC[C@@]21C
InChI
1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChI key
VOXZDWNPVJITMN-ZBRFXRBCSA-N
Gene Information
human ... ESR1(2099), ESR2(2100), ESRRA(2101), ESRRB(2103), GPER(2852), SERPINA6(866)
mouse ... Esr1(13982), Esr2(13983), Esrra(26379)
rat ... Afp(24177), Ar(24208), Esr1(24890), Esr2(25149), Shbg(24775)
General description
β-Estradiolis a natural steroid estrogen and a female sex hormone. It is an essential component of the female menstrual cycle and plays an important role in the growth and maintenance of the reproductive system.
Application
β-Estradiol has been used:
- for the in vitro maturation of bovine cumulus-oocyte complexes (COCs)
- as a supplement in in vitro maturation medium (IVM), which is used as a control medium
- in estrogen-induction assay[1]
Biochem/physiol Actions
The major estrogen secreted by the premenopausal ovary. Estrogens direct the development of the female phenotype in embryogenesis and during puberty by regulating gene transcription and, thus, protein synthesis. It also induces the production of gonadotropins which, in turn, induce ovulation. Exposure to estradiol increases breast cancer incidence and proliferation.
The major estrogen secreted by the premenopausal ovary.
Features and Benefits
This compound is featured on the Acetylcholine Receptors (Nicotinic) and Nuclear Receptors (Steroids) pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
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hcodes
signalword
Danger
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 1A
Classe de stockage
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.
Synthesis and electrochemical characterization of nanostructured magnetic molecularly imprinted polymers for 17-beta-Estradiol determination
Lahcen A, et al.
Sensors and Actuators B, Chemical, 241, 698-705 (2017)
Three-step in vitro maturation culture of bovine oocytes imitating temporal changes of estradiol-17beta and progesterone concentrations in preovulatory follicular fluid.
Matsuo M, et al.
Archives Animal Breeding, 60(4), 385-390 (2017)
Supra molecular mechanism of the removal of 17-beta-estradiol endocrine disturbing pollutant from water on functionalized iron nano particles
Ali I, et al.
Journal of Molecular Liquids, 241, 123-129 (2017)
Numéro d'article de commerce international
| Référence | GTIN |
|---|---|
| E8875-250MG | 04061835506309 |
| E8875-100G | 04061832284361 |
| E8875-1G | 04061835556762 |
| E8875-25G | 04061832867175 |
| E8875-5G | 04061835544684 |
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Is there an optimal concentration for dissolving E8875 in absolute ethanol? How long can the product be stored at 4°C? How about at -20°C? What is the maximum number of times the product can be thawed?
1 answer-
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Can I dissolve E8875-1G with ethanol and keep it below -20℃?
1 answer-
This product can be dissolved in ethanol and solutions can be stored in frozen aliquots avoiding repetitive freeze/thaws cycles.
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Which of the two options, E1024 or E8875, is preferable for use as 1) an oral supplement and 2) silastic tube release? Additionally, among these which one is better for dissolving estrogen in sesame oil.
1 answer-
The in vivo application is beyond the scope of product characterization efforts. However, for the specified applications, E8875 is highly recommended, as it has been well cited in the literature. The following publications may be of interest for protocol reference:
1. J Vis Exp. 2012 Jun 7;(64):e4013. Ovariectomy and 17β-estradiol replacement in rats and mice: a visual demonstration. PMID: 22710371
2. Am J Physiol Regul Integr Comp Physiol. 2009 Sep;297(3):R587-92. Loss of ovarian function in the VCD mouse-model of menopause leads to insulin resistance and a rapid progression into the metabolic syndrome. PMID: 19439618
3. Eur J Pharmacol. 2021 May 25;906:174175. Apigenin acts as a partial agonist action at estrogen receptors in vivo. PMID: 34048736
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