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D6140

Sigma-Aldrich

Demeclocycline hydrochloride

powder or crystals, suitable for cell culture

Synonyme(s) :

7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride

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About This Item

Formule empirique (notation de Hill):
C21H21ClN2O8 · HCl
Numéro CAS:
64-73-3
Poids moléculaire :
501.31
Numéro Beilstein :
3849198
Numéro CE :
200-592-2
Numéro MDL:
MFCD00082371
Code UNSPSC :
12352207
ID de substance PubChem :
24278380
Nomenclature NACRES :
NA.75

product name

Demeclocycline hydrochloride, powder or crystals

Pureté

89.5-102.0% anhydrous basis

Forme

powder or crystals

Technique(s)

cell culture | mammalian: suitable

Solubilité

soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)

Spectre d'activité de l'antibiotique

Gram-negative bacteria
Gram-positive bacteria

Mode d’action

protein synthesis | interferes

Température de stockage

−20°C

Chaîne SMILES 

Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O

InChI

1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1

Clé InChI

GVSJQNRGSCOSNJ-KBHRXELFSA-N

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Description générale

Chemical structure: tetracycline

Actions biochimiques/physiologiques

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.
Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.
Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Warning

Classification des risques

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3

Organes cibles

Respiratory system

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificats d'analyse (COA)

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Gabrielle E Foxa et al.
Methods in molecular biology (Clifton, N.J.), 2221, 165-191 (2020-09-27)
Our laboratories have used genetically engineered mouse models (GEMMs) to assess genetic contributions to skeletal diseases such as osteoporosis and osteoarthritis. Studies on the genetic contributions to OA are often done by assessing how GEMMs respond to surgical methods that
Peter F Day et al.
Journal of endodontics, 37(8), 1052-1057 (2011-07-19)
There is evidence to suggest that Ledermix, placed as an intervisit root canal dressing, might improve periodontal healing after replantation of avulsed teeth. As a part of a multicenter randomized controlled trial, we aimed to compare the effect of 2
B Athanassiadis et al.
Australian dental journal, 55(2), 150-155 (2010-07-08)
The in vitro antimicrobial activity of a series of endodontic medicaments and their bases against biofilms of Enterococcus faecalis was investigated. The medicaments tested were Pulpdent paste, Ledermix paste, a 50:50 Ledermix and Pulpdent mixture, and a replica of Ledermix
P Lenherr et al.
International endodontic journal, 45(10), 942-949 (2012-04-18)
To investigate the discoloration potential of endodontic materials using a bovine tooth model. Two hundred and 10 dentine-enamel cuboid blocks (10 × 10 × 3.5 mm) were prepared out of the middle thirds of bovine tooth crowns. Standardized cavities were
Judith Piet et al.
Calcified tissue international, 105(3), 316-330 (2019-06-28)
The mechano-adaptive response of bone to loading in the murine uniaxial tibial loading model is impaired in aged animals. Previous studies have shown that in aged mice, the amount of bone formed in response to loading is augmented when loads
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