Accéder au contenu
Merck
Toutes les photos(1)

Key Documents

B1265

Sigma-Aldrich

Anti-Human IgM (μ-chain specific)−Biotin antibody produced in goat

affinity isolated antibody, buffered aqueous solution

Se connecterpour consulter vos tarifs contractuels et ceux de votre entreprise/organisme


About This Item

Numéro MDL:
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.46

Source biologique

goat

Niveau de qualité

Conjugué

biotin conjugate

Forme d'anticorps

affinity isolated antibody

Type de produit anticorps

secondary antibodies

Clone

polyclonal

Forme

buffered aqueous solution

Technique(s)

direct ELISA: 1:20,000

Température de stockage

2-8°C

Modification post-traductionnelle de la cible

unmodified

Description générale

Human IgMs are the initial immunoglobulin isotypes that appear in blood in response to the first exposure to external antigens. IgMs have been implicated in CNS myelin repair and increased secretory IgM levels have been linked to rhino-conjunctivitis . Anti-Human IgM (μ-chain specific)-Biotin antibody is specific for human IgM and does not bind other human immunoglobulins.
IgM antibody is produced by B cells and plays a pivotal role in primary defence mechanism. The main function is to recognise and eliminate foreign invaders like bacteria and viruses, cellular waste as well as precancerous and cancerous lesions. Anti-human IgM (μ-chain specific) −biotin antibody can be used in micro ELISA to determine IgD isotype antibody to phosphorylcholine (PC) . Goat anti-human IgM antibodies react specifically with human IgM but not with other human immunoglobulins.

Immunogène

Purified human IgM
Purified human IgM.

Application

Anti-Human IgM (μ-chain specific)-Biotin antibody is suitable for use in ELISA (1:2000) .

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Vous ne trouvez pas le bon produit ?  

Essayez notre Outil de sélection de produits.

Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

nwg

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

Déjà en possession de ce produit ?

Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Charu Aggarwal et al.
Journal of virology, 95(23), e0061021-e0061021 (2021-09-16)
Plasmablasts represent a specialized class of antibody-secreting effector B cells that transiently appear in blood circulation following infection or vaccination. The expansion of these cells generally tends to be massive in patients with systemic infections such as dengue or Ebola
A Ripamonti et al.
Proceedings of the National Academy of Sciences of the United States of America, 114(48), 12797-12802 (2017-11-15)
Follicular helper T cells (TFHs) are a key component of adaptive immune responses as they help antibody production by B cells. Differentiation and function of TFH cells are controlled by the master gene BCL6, but it is largely unclear how
Miguel A Trujillo et al.
DNA and cell biology, 22(8), 513-523 (2003-10-21)
We examined the role of BCR cell membrane redistribution in anti-IgM-induced apoptosis in three human B cell lines, RA#1, 2G6, and MC116, that differ in their relative levels of sIgM expression. The apoptotic response was found to be dependent on
R Tisch et al.
Proceedings of the National Academy of Sciences of the United States of America, 85(18), 6914-6918 (1988-09-01)
Crosslinked IgM molecules expressed on the surface of immature B cells mediate responses that inhibit further development, in contrast to the activational and proliferative events that follow crosslinking of the mu heavy chain in mature B cells. Concomitant with this
Marta Vidal et al.
Journal of immunological methods, 455, 41-54 (2018-02-06)
Quantitative suspension arrays are powerful immunoassays to measure antibodies against multiple antigens in large numbers of samples in a short time and using few microliters. To identify antigen targets of immunity for vaccine development against complex microbes like Plasmodium falciparum

Notre équipe de scientifiques dispose d'une expérience dans tous les secteurs de la recherche, notamment en sciences de la vie, science des matériaux, synthèse chimique, chromatographie, analyse et dans de nombreux autres domaines..

Contacter notre Service technique