51120

Guanosine 5′-triphosphate sodium salt hydrate

≥90% (HPLC)

• Synonyme(s) : GTP, GTP-Na⁺ hydrate, 5′-GTP-Na₂
• Formule empirique (notation de Hill): C₁₀H₁₆N₅O₁₄P₃ · xNa⁺ · yH₂O
• Numéro CAS: 36051-31-7
• Poids moléculaire : 523.18 (anhydrous free acid basis)
• Numéro Beilstein : 4113439
• Numéro CE : 252-847-2
• Numéro MDL: MFCD00149227
• Code UNSPSC : 41106305
• ID de substance PubChem : 57651277
• Nomenclature NACRES : NA.51

Propriétés

• Pureté: ≥90% (HPLC)
• Forme: powder
• Activité optique: [α]20/D −24±2°, c = 1% in 0.5 M Na₂HPO₄
• Impuretés: ≤3 mol/mol water (NMR)
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: O.O.[Na+].[Na+].NC1=Nc2c(ncn2[C@@H]3O[C@H](COP(O)(=O)OP([O-])(=O)OP(O)([O-])=O)[C@@H](O)[C@H]3O)C(=O)N1
• InChI: 1S/C10H16N5O14P3.2Na.2H2O/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21;;;;/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18);;;2*1H2/q;2*+1;;/p-2/t3-,5-,6-,9-;;;;/m1..../s1
• Clé InChI: HPLNHYUZFVUXFJ-ZVQJTLEUSA-L

Description

Description générale

Guanosine 5′-triphosphate (GTP) is a purine trinucleotide. GTP is a substrate for a wide range of G-protein coupled receptor (GPCR) GTPases, as well as cell signaling and cycling-associated guanine nucleotide exchange factors (GEF). See product G3776 for RNA polymerase transcription and DNA or RNA biosynthesis applications.

Application

Guanosine 5′-triphosphate sodium salt hydrate has been used:

• as a component of the internal solution for astrocyte patch-clamp to monitor astrocyte calcium activity from mouse amygdala slices.
• in a solution for channel current recording in cell lines using a voltage-clamp technique.
• to prepare internal recording solution for injectoporation to deliver genes to mechanosensory hair cells.
• promoting the formation of G interface-mediated homodimers of human septin during the analysis of its oligomerization state by analytical size exclusion chromatography (SEC).

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type N95 (US)