487910-M

(±)-S-Nitroso-N-acetylpenicillamine

Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM).

• Synonyme(s) : (±)-S-Nitroso-N-acetylpenicillamine, SNAP
• Formule empirique (notation de Hill): C₇H₁₂N₂O₄S
• Numéro CAS: 79032-48-7
• Poids moléculaire : 220.25
• Code UNSPSC : 12352116

Propriétés

• Niveau de qualité: 100
• Pureté: ≥95% (HPLC)
• Forme: solid
• Fabricant/nom de marque: Calbiochem^®
• Conditions de stockage: OK to freeze; protect from light
• Couleur: pale green
• Solubilité: DMSO: 25 mg/mL; ethanol: 25 mg/mL; methanol: soluble
• Température de stockage: −20°C
• InChI: 1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)
• Clé InChI: ZIIQCSMRQKCOCT-UHFFFAOYSA-N

Description

Description générale

Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t_1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.

Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM). Markedly activates soluble guanylate cyclase. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.

Actions biochimiques/physiologiques

EC50 = 130 nM in relaxation of isolated bovine coronary artery rings

Primary Target
Nitric oxide donor

Avertissement

Toxicity: Irritant (B)

Reconstitution

SNAP evolves NO immediately upon solubilization; reconstitute just prior to use.

Autres remarques

Nishio, E., et al. 1996. Biochem. Biophys. Res. Commun.221, 163.
Askew, S.C., et al. 1995. Bioorg. Med. Chem.3, 1.
Fehsel, K., et al. 1995. J. Immunol.155, 2858.
Gopalkrishna, R., et al. 1993. J. Biol. Chem.268, 27180.
Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther.248, 762.

Informations légales

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable