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Key Documents

23-034-M

Sigma-Aldrich

p53 Protein, 10 µg

Full length, recombinant human p53. N-terminal c-Myc, 6His-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

Synonyme(s) :

Cellular tumour antigen p53, Antigen NY-CO-13, Phosphoprotein p53, Tumour suppressor p53, TP53

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About This Item

Code UNSPSC :
12352202
eCl@ss :
32160405
Nomenclature NACRES :
NA.41

Source biologique

human

Niveau de qualité

100

Produit recombinant

expressed in E. coli

Forme

liquid

Fabricant/nom de marque

Upstate®

Technique(s)

activity assay: suitable

Solubilité

water: soluble

Numéro d'accès GenBank

BC003596

Température de stockage

−70°C

Informations sur le gène

human ... TP53(120407068)

Description générale

Research area: Apoptosis

N-terminal GST-tagged, recombinant human TRAF6 full length, expressed in E.coli. The p53 protein is a tumor suppressor encoded by TP53 gene located on chromosome 17.

Application

Ubiquitination Cascade Comoponent: Substrate

Actions biochimiques/physiologiques

p53 is expressed in a wide variety of tissues and plays a major role in preventing tumour development. It is involved in cell cycle regulation, functioning as a trans-activator to negatively regulate cell division by controlling a set of genes required for this process. It acts as a tumour suppressor in many tumour types by stimulating either apoptosis or growth arrest, depending on the physiological circumstances and the cell type. Defects in p53 expression have been implicated in several diseases, including choroid plexus papilloma, lung cancer, head/neck squamous cell carcinomas, oesophageal squamous cell carcinoma, Li-Fraumeni syndrome, and hereditary adrenocortical carcinoma.

Forme physique

Purified using immobilized metal affinity chromatography.

Autres remarques

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Informations légales

GenBank is a registered trademark of United States Department of Health and Human Services
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Pictogrammes

Exclamation mark
GHS07

Mention d'avertissement

Warning

Mentions de danger

H317

Classification des risques

Skin Sens. 1

Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

The p53 tumor suppressor protein
Genes & diseases (1998)
Hany E Marei et al.
Cancer cell international, 21(1), 703-703 (2021-12-26)
The p53 protein is a transcription factor known as the "guardian of the genome" because of its critical function in preserving genomic integrity. The TP53 gene is mutated in approximately half of all human malignancies, including those of the breast

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