1.01005

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate

EMPROVE^® ESSENTIAL, Ph. Eur., BP, JP, NF

• Synonyme(s) : 1,1,1-Trichloro-2-methyl-2-propanol hemihydrate, Acetone chloroform, Chlorbutol, Chloretone, Chlorobutanol
• Formule empirique (notation de Hill): C₄H₇Cl₃O · 0.5H₂O
• Numéro CAS: 6001-64-5
• Poids moléculaire : 186.46
• Numéro MDL: MFCD02179352
• Code UNSPSC : 12352104
• Numéro de classement CE : 200-317-6

Propriétés

• Agence: BP; JP; NF; Ph. Eur.
• Niveau de qualité: 500
• Gamme de produits: EMPROVE^® ESSENTIAL
• Forme: solid
• pH: 4.5-6 (20 °C, 7.7 g/L in H₂O)
• Point d'ébullition: 167 °C/1013 hPa
• Pf: 78 °C
• Température de transition: flash point 100 °C
• Solubilité: 7.7 g/L
• Application(s): liquid formulation; ophthalmics; pharmaceutical
• Température de stockage: 15-25°C
• InChI: 1S/2C4H7Cl3O.H2O/c2*1-3(2,8)4(5,6)7;/h2*8H,1-2H3;1H2
• Clé InChI: WRWLCXJYIMRJIN-UHFFFAOYSA-N

Description

Description générale

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production.
As part of our Emprove^® Program, our raw materials are offered with extensive documentation facilitating compliance of your pharma and biopharma product, full supply chain transparency and risk mitigation. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

1,1,1-Trichloro-2-methyl-2-propanol hemihydrate (chlorobutanol) is typically used as a preservative in pharmaceutical formulations. It has antimicrobial properties and is active against bacteria and fungi.

Informations légales

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Clause de non-responsabilité

The substance 1.01005 has no REACH registration because the only supported use is the use in medicinal products for human or veterinary use or in food or feedingstuffs according to article 2 of the REACH Regulation (EC) No 1907/2006.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302
• Conseils de prudence: P264 - P270 - P301 + P312 - P501
• Classification des risques: Acute Tox. 4 Oral
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): 212.0 °F - closed cup
• Point d'éclair (°C): 100 °C - closed cup