N-920

Norbuprenorphine-D₃ solution

100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant^®

• Synonyme(s) : Norbuprenorphine-d₃
• Formule empirique (notation de Hill): C₂₅H₃₂D₃NO₄
• Numéro CAS: 350482-19-8
• Poids moléculaire : 416.57
• Numéro CE : 200-659-6
• Numéro MDL: MFCD01861544
• Code UNSPSC : 41116107
• ID de substance PubChem : 329818614
• Nomenclature NACRES : NA.24

Propriétés

• Qualité: certified reference material
• Forme: liquid
• Caractéristiques: Snap-N-Spike^®/Snap-N-Shoot^®
• Conditionnement: ampule of 1 mL
• Fabricant/nom de marque: Cerilliant^®
• drug control: Narcotic Licence Schedule A (Switzerland)
• Concentration: 100 μg/mL in methanol
• Technique(s): gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• Application(s): forensics and toxicology
• Format: single component solution
• Température de stockage: −20°C
• Chaîne SMILES: [2H]C([2H])([2H])O[C@]12CC[C@@]3(C[C@@H]1[C@](C)(O)C(C)(C)C)[C@H]4Cc5ccc(O)c6O[C@@H]2[C@]3(CCN4)c56
• InChI: 1S/C25H35NO4/c1-21(2,3)22(4,28)16-13-23-8-9-25(16,29-5)20-24(23)10-11-26-17(23)12-14-6-7-15(27)19(30-20)18(14)24/h6-7,16-17,20,26-28H,8-13H2,1-5H3/t16-,17-,20-,22+,23-,24+,25-/m1/s1/i5D3
• Clé InChI: YOYLLRBMGQRFTN-QLWKBOQPSA-N

Description

Description générale

Norbuprenorphine is the primary active metabolite of the opiate buprenorphine in urine. This internal standard is suitable for quantitation of norbuprenorphine levels or isotope dilution methods by GC/MS or LC/MS for pain prescription monitoring, clinical toxicology, urine drug testing or forensic analysis. Buprenorphine, sold under trade names such as Buprenex^®, Subutex^® and Suboxone^®, is an opiate drug used to treat opioid addiction and moderate to acute pain.

Application

• Improving GC-MS Analysis of Norbuprenorphine: A study by Gervais JR and Hobbs GA discusses the use of an acetyl derivative to enhance the GC-MS analysis of Norbuprenorphine in urine, particularly in the presence of high concentrations of Buprenorphine, highlighting its significance as an analytical standard in forensic and clinical toxicology (Gervais and Hobbs, 2016).
• Quantification of Acetaminophen Protein Adducts: Cook SF et al. developed a method for the quantification of a biomarker for acetaminophen protein adducts in human serum using high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry. This study demonstrates the application of advanced analytical techniques in toxicology and pharmacokinetics, where Norbuprenorphine-D3 serves as a reliable internal standard (Cook et al., 2015).

Informations légales

Buprenex is a registered trademark of Reckitt & Colman (Overseas) Ltd

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Suboxone is a registered trademark of RB Pharmaceuticals Limited

Subutex is a registered trademark of RB Pharmaceuticals Limited

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H225,H301 + H311 + H331,H370
• Conseils de prudence: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Organes cibles: Eyes
• Code de la classe de stockage: 3 - Flammable liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): 49.5 °F - closed cup
• Point d'éclair (°C): 9.7 °C - closed cup