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880124X

Avanti

DSPE-PEG(2000) Folate

Avanti Research™ - A Croda Brand 880124X

Synonyme(s) :

1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000] (ammonium salt):methanol (9:1)

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About This Item

Numéro CAS:
1236288-25-7
Code UNSPSC :
12352211
Nomenclature NACRES :
NA.25

Forme

liquid

Conditionnement

pkg of 1 × 1 mL (880124X-10mg)
pkg of 1 × 1 mL (880124X-1mg)

Fabricant/nom de marque

Avanti Research™ - A Croda Brand 880124X

Concentration

1 mg/mL (880124X-1mg)
10 mg/mL (880124X-10mg)

Conditions d'expédition

dry ice

Température de stockage

−20°C

Description générale

DSPE-PEG(2000) Folate, also known as 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000], is a functionalized PEG lipid. This lipid is added into liposomes as a targeting ligand for folate receptors, which acts as cellular surface markers for numerous solid tumors and myeloid leukemias. Folate targeted drug delivery is used an effective therapy for the treatment and imaging of various cancers and inflammatory diseases. Folate conjugates with low molecular weight and high binding affinity for folate receptors (FR) on cell surface deliver a variety of molecular complexes such as protein toxins, immune stimulants, chemotherapeutic agents, liposomes, nanoparticles, and imaging agents to pathologic cells without affecting normal tissues.

Application

DSPE-PEG(2000) Folate(1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[folate(polyethylene glycol)-2000]) may be used in preparation of folate-conjugated liposomes and folate-modified microvesicles (MVs).

Conditionnement

5 mL Clear Glass Sealed Ampule (880124X-10mg)
5 mL Clear Glass Sealed Ampule (880124X-1mg)

Informations légales

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pictogrammes

FlameSkull and crossbonesHealth hazard
GHS02,GHS06,GHS08

Mention d'avertissement

Danger

Classification des risques

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 3 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 Oral - STOT SE 2 - STOT SE 3

Organes cibles

Eyes,Central nervous system, Liver,Kidney, Respiratory system

Code de la classe de stockage

3 - Flammable liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

80.6 °F

Point d'éclair (°C)

27 °C

Certificats d'analyse (COA)

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Controlled gene and drug release from a liposomal delivery platform triggered by X-ray radiation
Deng W, et al.
Nature Communications, 9(1) (2018)
Wei Deng et al.
Nature communications, 9(1), 2713-2713 (2018-07-15)
Liposomes have been well established as an effective drug delivery system, due to simplicity of their preparation and unique characteristics. However conventional liposomes are unsuitable for the on-demand content release, which limits their therapeutic utility. Here we report X-ray-triggerable liposomes
Magnetic and folate functionalization enables rapid isolation and enhanced tumor-targeting of cell-derived microvesicles
Zhang W, et al.
ACS Nano, 11(1), 277-290 (2017)
Andrew R Hilgenbrink et al.
Journal of pharmaceutical sciences, 94(10), 2135-2146 (2005-09-02)
Folate targeted drug delivery has emerged as an alternative therapy for the treatment and imaging of many cancers and inflammatory diseases. Due to its small molecular size and high binding affinity for cell surface folate receptors (FR), folate conjugates have
Wei Zhang et al.
ACS nano, 11(1), 277-290 (2016-12-23)
Cell-derived microvesicles (MVs), which are biogenic nanosized membrane-bound vesicles that convey bioactive molecules between cells, have recently received attention for use as natural therapeutic platforms. However, the medical applications of MV-based delivery platforms are limited by the lack of effective
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