P2066

Poly(D,L-lactide-co-glycolide)

lactide:glycolide 65:35, M_w 40,000-75,000

• Synonyme(s) : Lactel^® B6001-1, PLGA
• Formule linéaire : [C₃H₄O₂]_x[C₂H₂O₂]_y
• Numéro MDL: MFCD00131930
• Code UNSPSC : 12162002
• ID de substance PubChem : 24898268
• Nomenclature NACRES : NA.23

Propriétés

• Forme: pellets
• Niveau de qualité: 100
• Ratio alimentaire: lactide:glycolide 65:35
• Poids mol.: M_w 40,000-75,000
• Température de stockage: −20°C
• Chaîne SMILES: OCC(O)=O.CC(O)C(O)=O

Description

Application

• Inhaled Macrophage Apoptotic Bodies-Engineered Microparticle Enabling Construction of Pro-Regenerative Microenvironment to Fight Hypoxic Lung Injury in Mice.: This study demonstrates the use of Poly(ᴅ,ʟ-lactide-co-glycolide) (PLGA) in engineering microparticles that promote lung tissue regeneration in hypoxic conditions, highlighting its potential in developing advanced therapeutic strategies for respiratory injuries (Liu et al., 2024).


• Engineered nanoparticles promote cardiac tropism of AAV vectors.: The research explores the role of PLGA nanoparticles in enhancing the targeting efficiency of AAV vectors to cardiac tissues, showcasing its application in gene therapy and cardiovascular disease treatment (Switala et al., 2024).


• Drug-loaded adhesive microparticles for biofilm prevention on oral surfaces.: This article reports the development of drug-loaded PLGA microparticles designed to prevent biofilm formation on oral surfaces, demonstrating the polymer′s utility in dental applications and biofilm-associated infections (Oh et al., 2024).


• Dual-layer conduit containing VEGF-A - Transfected Schwann cells promotes peripheral nerve regeneration via angiogenesis.: PLGA-based dual-layer conduits are utilized to support nerve regeneration by enhancing angiogenesis, indicating its importance in neuroregenerative medicine and peripheral nerve injury treatments (Huang et al., 2024).


• Application of Doxorubicin-loaded PLGA nanoparticles targeting both tumor cells and cancer-associated fibroblasts on 3D human skin equivalents mimicking melanoma and cutaneous squamous cell carcinoma.: The study highlights the dual-targeting capability of PLGA nanoparticles in delivering chemotherapy drugs to both tumor cells and the surrounding supportive stroma, emphasizing its role in advanced cancer therapies (He et al., 2024).

Caractéristiques et avantages

Controlled release of bioactive agents, sutures and bioabsorbable implantable devices.

Forme physique

Biocompatible, biodegradable polymer.

Informations légales

Lactel is a registered trademark of Evonik Corp

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)