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692905

Sigma-Aldrich

N-Ethyl-d5-maleimide

99 atom % D, 98% (CP)

Synonyme(s) :

NEM (ethyl-d5)

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About This Item

Formule empirique (notation de Hill):
C6D5H2NO2
Numéro CAS:
Poids moléculaire :
130.16
Numéro MDL:
Code UNSPSC :
12352005
ID de substance PubChem :
Nomenclature NACRES :
NA.13

Pureté isotopique

99 atom % D

Niveau de qualité

Pureté

98% (CP)

Forme

powder

Pf

43-46 °C (lit.)

Changement de masse

M+5

Température de stockage

2-8°C

Chaîne SMILES 

[2H]C([2H])([2H])C([2H])([2H])N1C(=O)C=CC1=O

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3/i1D3,2D2

Clé InChI

HDFGOPSGAURCEO-ZBJDZAJPSA-N

Description générale

N-Ethyl-d5-maleimide is a deuterated isotope analog of N-ethymaleimide, wherein methylene and methyl protons are replaced by deuterium.

Application

N-Ethyl-d5-maleimide can be used:
  • To synthesize isotopic silica nanotag by reacting with silica precursor 3-mercaptopropyltrimethoxysilane (MPTMS) for multiplexed ion beam imaging.
  • As an isotopic internal standard to determine the ratio of glutathione (GSH) and glutathione disulfide (GSSG) in cultured cells using HPLC-UV and LC-QTOF-MS.

Conditionnement

This product may be available from bulk stock and can be packaged on demand. For information on pricing, availability and packaging, please contact Stable Isotopes Customer Service.

Pictogrammes

Skull and crossbonesCorrosion

Mention d'avertissement

Danger

Mentions de danger

Classification des risques

Acute Tox. 2 Oral - Acute Tox. 3 Dermal - Eye Dam. 1 - Skin Corr. 1B - Skin Sens. 1

Code de la classe de stockage

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

163.4 °F - closed cup

Point d'éclair (°C)

73 °C - closed cup


Certificats d'analyse (COA)

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Advanced materials technologies, 5(7) (2020-07-15)
High-dimensional profiling of markers and analytes using approaches, such as barcoded fluorescent imaging with repeated labeling and mass cytometry has allowed visualization of biological processes at the single-cell level. To address limitations of sensitivity and mass-channel capacity, a nanobarcoding platform
T R Sutton et al.
Redox biology, 16, 359-380 (2018-04-09)
Several diseases are associated with perturbations in redox signaling and aberrant hydrogen sulfide metabolism, and numerous analytical methods exist for the measurement of the sulfur-containing species affected. However, uncertainty remains about their concentrations and speciation in cells/biofluids, perhaps in part
Xueni Sun et al.
Metabolites, 10(7) (2020-07-28)
Glutathione (GSH) and glutathione disulfide (GSSG) are commonly used to assess the oxidative status of a biological system. Various protocols are available for the analysis of GSH and GSSG in biomedical specimens. In this study, we present an optimized protocol
Isotopically Encoded Nanotags for Multiplexed Ion Beam Imaging
Harmsen S, et al.
Advanced Materials Technologies, 5(7), 2000098-2000098 (2020)
Optimized Protocol for the In Situ Derivatization of Glutathione with N-Ethylmaleimide in Cultured Cells and the Simultaneous Determination of Glutathione/Glutathione Disulfide Ratio by HPLC-UV-QTOF-MS
Sun X, et al.
Metabolites, 10(7), 292-292 (2020)

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