MAB3564
Anti-Sodium/Iodine Symporter Antibody, a.a. 625-643, clone FP5A
clone FP5A, Chemicon®, from mouse
Synonym(s):
Na+/I- Symporter, NIS
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About This Item
UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41
Recommended Products
biological source
mouse
Quality Level
antibody form
purified antibody
antibody product type
primary antibodies
clone
FP5A, monoclonal
species reactivity
human
manufacturer/tradename
Chemicon®
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
western blot: suitable
isotype
IgG1κ
NCBI accession no.
UniProt accession no.
shipped in
wet ice
target post-translational modification
unmodified
Gene Information
human ... SLC5A5(6528)
Specificity
Sodium/Iodide Symporter (NIS). The epitope is thought to be in the region of amino acids 625-643 of human NIS. The antibody may show some reactivity to Maltose Binding Protein.
Immunogen
Epitope: a.a. 625-643
Maltose Binding Protein fusion protein corresponding to amino acids 468-643 of human NIS (C-terminus).
Application
Detect Sodium/Iodine Symporter using this Anti-Sodium/Iodine Symporter Antibody, a.a. 625-643, clone FP5A validated for use in IH, IH(P) & WB.
Immunoblotting. The antibody recognizes a major band at ~97 kDa and minor bands at 15 kDa, 30 kDa, 68 kDa and 160 kDa.
Immunohistochemistry. The antibody works on paraffin embedded tissue sections which have been subjected to antigen retrieval with 10 mM citrate buffer steam for 30 minutes.
Optimal working dilutions must be determined by end user.
Immunohistochemistry. The antibody works on paraffin embedded tissue sections which have been subjected to antigen retrieval with 10 mM citrate buffer steam for 30 minutes.
Optimal working dilutions must be determined by end user.
Physical form
Format: Purified
Other Notes
Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
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Storage Class Code
10 - Combustible liquids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Christina Schug et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 25(19), 5997-6008 (2019-06-15)
The innate tumor homing potential of mesenchymal stem cells (MSCs) has been used for a targeted delivery of the theranostic sodium iodide symporter (NIS) transgene into solid tumors. We have previously shown that external beam radiotherapy (EBRT) results in the
Annie Yang et al.
Journal for immunotherapy of cancer, 11(4) (2023-04-06)
Gastric cancer (GC) that metastasizes to the peritoneum is fatal. CF33 and its genetically modified derivatives show cancer selectivity and oncolytic potency against various solid tumors. CF33-hNIS and CF33-hNIS-antiPDL1 have entered phase I trials for intratumoral and intravenous treatments of
Carolin Kitzberger et al.
Molecular therapy oncolytics, 30, 238-253 (2023-09-13)
New treatment strategies are urgently needed for glioblastoma (GBM)-a tumor resistant to standard-of-care treatment with a high risk of recurrence and extremely poor prognosis. Based on their intrinsic tumor tropism, adoptively applied mesenchymal stem cells (MSCs) can be harnessed to
Rebekka Spellerberg et al.
Molecular therapy oncolytics, 27, 272-287 (2022-12-03)
Sodium iodide symporter (NIS) gene transfer for active accumulation of iodide in tumor cells is a powerful theranostic strategy facilitating both diagnostic and therapeutic application of radioiodide. In glioblastoma (GBM), the blood-brain barrier (BBB) presents an additional delivery barrier for
Danielle L Gainor et al.
JAMA otolaryngology-- head & neck surgery, 141(8), 739-744 (2015-06-05)
Sodium iodide symporter (NIS) expression in adenoid cystic carcinoma (ACC) has not been fully elucidated in the literature, and it is unclear whether radioactive iodine may be a potential therapeutic modality. To our knowledge, the present study includes the largest
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