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Injectable and tunable poly(ethylene glycol) analogue hydrogels based on poly(oligoethylene glycol methacrylate).

Chemical communications (Cambridge, England) (2014-02-18)
Niels M B Smeets, Emilia Bakaic, Mathew Patenaude, Todd Hoare
RÉSUMÉ

Injectable PEG-analogue hydrogels based on poly(oligoethylene glycol methacrylate) have been developed based on complementary hydrazide and aldehyde reactive linear polymer precursors. These hydrogels display the desired biological properties of PEG, form covalent networks in situ following injection, and are easily modulated for improved control over their functionality and physiochemical properties.

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Sigma-Aldrich
Poly(OEGMA), hydrazide functionalized, 25 wt% solution in water
Sigma-Aldrich
Poly(M(EO)2MA:Poly(OEGMA), (90:10), aldehyde functionalized, 25 wt% solution in water
Sigma-Aldrich
Poly(M(EO)2MA:Poly(OEGMA) 90:10, hydrazide functionalized, 25 wt. % (solution in water)