- Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
Discorhabdin alkaloids from Antarctic Latrunculia spp. sponges as a new class of cholinesterase inhibitors.
European journal of medicinal chemistry (2017-05-16)
Tanja Botić, Andrea Defant, Pietro Zanini, Monika Cecilija Žužek, Robert Frangež, Dorte Janussen, Daniel Kersken, Željko Knez, Ines Mancini, Kristina Sepčić
PMID28505534
RÉSUMÉ
The brominated pyrroloiminoquinone alkaloids discorhabdins B, L and G and 3-dihydro-7,8- dehydrodiscorhabdin C, isolated from methanol extracts of two specimens of Latrunculia sp. sponges collected near the Antarctic Peninsula, are here demonstrated for the first time to be reversible competitive inhibitors of cholinesterases. They showed K
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