- Cloning of a putative ligand for the T1/ST2 receptor.
Cloning of a putative ligand for the T1/ST2 receptor.
The Journal of biological chemistry (1996-03-08)
M A Gayle, J L Slack, T P Bonnert, B R Renshaw, G Sonoda, T Taguchi, J R Testa, S K Dower, J E Sims
PMID8621446
RÉSUMÉ
T1/ST2 is a receptor-like molecule homologous to the type I interleukin-1 receptor. Despite this sequence similarity, we have been unable to demonstrate binding of T1/ST2 to any of the three interleukin-1 species. In searching for a ligand for T1/ST2, we have cloned a cell surface protein to which it binds. This protein is unable to initiate signal transduction by the T1/ST2 receptor in several in vitro assays.