- Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences.
Glucuronidation of aurantio-obtusin: identification of human UDP-glucuronosyltransferases and species differences.
Xenobiotica; the fate of foreign compounds in biological systems (2014-03-13)
Bao-Li Mi, Qi Sun, Yan-Qing Qu, Xiao-Xu Gao, Zhen-Wen Yu, Guang-Bo Ge, Shan-Shan Cai, Jie Zhang, Yan-Chao Zheng, Zhen-Qiu Zhang
PMID24618000
RÉSUMÉ
1. The aurantio-obtusin's glucuronide was detected when aurantio-obtusin was incubated with human liver microsomes (HLMs). Recombinant UGT isoforms screening experiment showed that UGT1A8 was the major isoform contributed to the glucuronidation. 2. The metabolic profiles for aurantio-obtusin in liver microsomes from different species were similar, however, the intrinsic clearance values (Vmax/Km) among the species were: Monkey > Human > Rat > Rabbit > Dog > Pig > Mouse > Guinea pig.