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Synthesis of novel highly functionalized 4-thiazolidinone derivatives from 4-phenyl-3-thiosemicarbazones.

Molecules (Basel, Switzerland) (2014-03-13)
Abdelmadjid Benmohammed, Omar Khoumeri, Ayada Djafri, Thierry Terme, Patrice Vanelle
RÉSUMÉ

We present herein the synthesis in good yields of two series of highly functionalized thiazolidinone derivatives from the reactions of various 4-phenyl-3-thio-semicarbazones with ethyl 2-bromoacetate and diethyl acetylenedicarboxylate, respectively.

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Diethyl acetylenedicarboxylate, 95%