Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Quinolones and non-steroidal anti-inflammatory drugs interacting with copper(II), nickel(II), cobalt(II) and zinc(II): structural features, biological evaluation and perspectives.

Dalton transactions (Cambridge, England : 2003) (2013-03-27)

George Psomas, Dimitris P Kessissoglou

RÉSUMÉ

The structural features of copper(II), nickel(II), cobalt(II) and zinc(II) complexes with the antimicrobial drugs quinolones and non-steroidal anti-inflammatory drugs (NSAIDs) as ligands are discussed. The binding properties of these complexes to biomolecules (calf-thymus DNA, bovine or human serum albumin) are presented and evaluated. The biological activity (antimicrobial, antioxidant and antiproliferative) of selected complexes is investigated. Further perspectives concerning the synthesis and the biological activity of novel complexes with quinolones or NSAIDs attractive to synthetic chemists, biochemists and/or biologists are presented.

MATÉRIAUX

Référence du produit

Marque

Description du produit

221678

Sigma-Aldrich

Nickel de Raney^®, W.R. Grace and Co. Raney^® 2800, slurry, in H₂O, active catalyst

577995

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Nickel, nanopowder, <100 nm avg. part. size, ≥99% trace metals basis

266639

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Cobalt, powder, 2 μm particle size, 99.8% trace metals basis

510033

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Nickel de Raney^®, W.R. Grace and Co. Raney^® 2400, slurry, in H₂O, active catalyst

266981

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203904

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Nickel, powder, <150 μm, 99.99% trace metals basis

266647

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Cobalt, powder, <150 μm, ≥99.9% trace metals basis

268259

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Nickel, foil, thickness 0.125 mm, ≥99.9%

510041

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Nickel de Raney^®, W.R. Grace and Co. Raney^® 4200, slurry, in H₂O, active catalyst

357634

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203076

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Cobalt, granular, 99.99% trace metals basis

268283

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357553

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510068

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266655

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Cobalt, pieces, 99.5% trace metals basis

267074

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356867

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398810

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