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Pd-catalyzed C3-selective arylation of pyridines with phenyl tosylates.

Chemical communications (Cambridge, England) (2013-04-12)
Fenglin Dai, Qingwen Gui, Jidan Liu, Zhiyong Yang, Xiang Chen, Ruqing Guo, Ze Tan
RÉSUMÉ

We have discovered that phenyl tosylates can be used to arylate pyridines at the C3-position using a Pd(OAc)2-1,10-phenanthroline catalyst system. We also discovered that the reaction of 4-methylpyridine with naphthyl tosylates occurred on the methyl group instead of at the C3-position.

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4-Methylpyridine, 99%