- In vitro degradation of substance P: new rapid assay and distribution in rat brain.
In vitro degradation of substance P: new rapid assay and distribution in rat brain.
Acta biologica et medica Germanica (1981-01-01)
T N Akopyan, H Berger, B Mehlis, P Oehme, A A Galoyan
PMID6172920
RÉSUMÉ
An ion exchange batchwise procedure was developed for the estimation of substance P degradation by rat brain fractions using 3H[Nle11]substance P as tracer. With this very sensitive and rapid method an especially high degradative activity was found among others in the microsomal fractions of the striatum.