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Identification of urinary metabolites in rats exposed to the nephrotoxic agent 2,3,4-trimethylpentane.

Biomedical & environmental mass spectrometry (1987-11-01)
K O Yu, C T Olson, D W Hobson, M P Serve
RÉSUMÉ

Branched-chain hydrocarbon-induced nephropathy in male rats was examined using 2,3,4-trimethylpentane. Lesions are elected only in male rats, not in females or in controls. Mechanisms of nephropathy may be the interaction of metabolites with the male rat-specific protein alpha 2u globulin. The identified urinary metabolites of 2,3,4-trimethylpentane in male rats given the hydrocarbon by gavage are 2,3,4-trimethyl-1-pentanol, 2,3,4-trimethyl-2-pentanol and 2,3,4-trimethyl-1-pentanoic acid. Of the C8-isomers, 2,3,4-trimethylpentane dosing leads to the highest incidence of kidney damage in male rats.

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2,3,4-Trimethylpentane, 98%