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Continuous-flow synthesis of monoarylated acetaldehydes using aryldiazonium salts.

Journal of the American Chemical Society (2012-07-21)
Natalia Chernyak, Stephen L Buchwald
RÉSUMÉ

Anilines and ethyl vinyl ether can be used as precursors for a process that is the synthetic equivalent of the α-arylation of acetaldehyde enolate. The reaction manifests a high level of functional group compatibility, allowing the ready preparation of a number of synthetically valuable compounds.

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Ethyl vinyl ether, contains 0.1% KOH as stabilizer, 99%