- Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration.
Reproducibility of neutron activated Sm-153 oral dose formulations intended for human administration.
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (2011-05-10)
C H Yeong, P E Blackshaw, K H Ng, B J J Abdullah, M Blaauw, R J Dansereau, A C Perkins
PMID21550260
RÉSUMÉ
Neutron activation of Sm-152 offers a method of radiolabeling for the in vivo study of oral dose formulations by gamma scintigraphy. Reproducibility measurements are needed to ensure the robustness of clinical studies. 204 enteric-coated guaifenesin core tablets (10mg of Sm(2)O(3)) were irradiated by thermal neutrons to achieve 1 MBq at 48 h. Administered activities were 0.86±0.03 MBq. Good reproducibility (CV=3.5%) was observed over 24 weeks ensuring that volunteer doses were within the dose reference level of 0.8 mSv.