- Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA.
Sensitive fluorescence biosensor for folate receptor based on terminal protection of small-molecule-linked DNA.
Chemical communications (Cambridge, England) (2012-05-17)
Xiaofeng Wei, Wenlie Lin, Na Ma, Fang Luo, Zhenyu Lin, Longhua Guo, Bin Qiu, Guonan Chen
PMID22590712
RÉSUMÉ
Based on the specific folic acid-folate receptor (FA-FR) interaction, macromolecular FR can bind with FA-linked DNA-small molecule chimeras, which can prevent enzymolysis by exonuclease III (Exo III), enabling a novel fluorescence biosensor for FR to be developed using quinaldine red as a G-quadruplex-binding probe.