In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

In vitro activities of cloxyquin (5-chloroquinolin-8-ol) against Mycobacterium tuberculosis.

Antimicrobial agents and chemotherapy (2006-12-21)

Poonpilas Hongmanee, Kamolchanok Rukseree, Benjamas Buabut, Boontiwa Somsri, Prasit Palittapongarnpim

RÉSUMÉ

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.

MATÉRIAUX

Référence du produit

Marque

Description du produit

252565

Sigma-Aldrich

8-Quinolinol, ACS reagent, 98.5%

C47000

Sigma-Aldrich

5-Chloro-8-quinolinol, 95%

H6878

Sigma-Aldrich