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T3077

Sigma-Aldrich

TRO 19622

≥98% (HPLC), solid

Synonyme(s) :

NSC 21311, cholest-4-en-3-one, oxime

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About This Item

Formule empirique (notation de Hill):
C27H45NO
Numéro CAS:
22033-87-0
Poids moléculaire :
399.65
Code UNSPSC :
12352200
Nomenclature NACRES :
NA.77

Niveau de qualité

100

Pureté

≥98% (HPLC)

Forme

solid

Couleur

white

Solubilité

DMSO: >10 mg/mL

Température de stockage

−20°C

InChI

1S/C27H45NO/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28-29)13-15-26(20,4)25(22)14-16-27(23,24)5/h17-19,22-25,29H,6-16H2,1-5H3/b28-21+

Clé InChI

QNTASHOAVRSLMD-SGWCAAJKSA-N

Application

TRO 19622 has been used as a mitochondrial permeability transition pore inhibitor in mouse neurons2. TRO 19622 is also known to stimulate myelin repair in rat models of demyelination3.

Actions biochimiques/physiologiques

TRO 19622 can decrease axonal degradation and enhance the rescue of motor nerve conduction in peripheral neuropathy. Furthermore, TRO 19622 can reverse neuropathic pain and tactile allodynia in rat models of diabetes and chemotherapy-induced neuropathic pain4.
TRO19622 ia a neuroprotective agent for motor neurons; candidate therapeutic for amyotrophic lateral sclerosis (ALS).

Notes préparatoires

TRO 19622 is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Consulter la Bibliothèque de documents

Lee J Martin et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(1), 359-370 (2011-01-07)
Ablation of mouse occipital cortex induces precisely timed and uniform p53-modulated and Bax-dependent apoptosis of thalamocortical projection neurons in the dorsal lateral geniculate nucleus (LGN) by 7 d after lesion. We tested the hypothesis that this neuronal apoptosis is initiated
Yiqiao Li et al.
The International journal of neuroscience, 123(11), 810-822 (2013-05-15)
Multiple sclerosis is a neurodegenerative autoimmune disease characterized by diffuse oligodendrocyte injury, axonal loss and multifocal demyelination of myelin sheaths in the central nervous system. TRO19622 is a small cholesterol-like compound, which displays remarkable neuroprotective and neuroregenerative properties in neural
Thierry Bordet et al.
The Journal of pharmacology and experimental therapeutics, 322(2), 709-720 (2007-05-15)
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive death of cortical and spinal motor neurons, for which there is no effective treatment. Using a cell-based assay for compounds capable of preventing motor neuron cell death in
Lyudmila I Rachek et al.
Toxicology and applied pharmacology, 240(3), 348-354 (2009-07-28)
Thiazolidinediones (TZDs), such as troglitazone (TRO) and rosiglitazone (ROSI), improve insulin resistance by acting as ligands for the nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma). TRO was withdrawn from the market because of reports of serious hepatotoxicity. A growing body of
Thierry Bordet et al.
The Journal of pharmacology and experimental therapeutics, 326(2), 623-632 (2008-05-22)
Diabetes and cancer chemotherapies are often associated with painful neuropathy. The mechanisms underlying neuropathic pain remain poorly understood, and the current therapies have limited efficacy and are associated with dose-limiting side effects. We recently described the pharmacological characterization of cholest-4-en-3-one
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