N2286

Nonactin

from Streptomyces griseus, ≥98.0% (Total homologs, HPLC)

• Synonyme(s) : Ammonium ionophore I, Ammonium ionophore
• Formule empirique (notation de Hill): C₄₀H₆₄O₁₂
• Numéro CAS: 6833-84-7
• Poids moléculaire : 736.93
• Beilstein: 76434
• Numéro CE : 229-911-3
• Code UNSPSC : 51102829
• ID de substance PubChem : 24897566
• Nomenclature NACRES : NA.76

Propriétés

• Source biologique: Streptomyces griseus
• Niveau de qualité: 300
• Description: Natural macrotetrolide, may contain homologues (like monactin and dinactin)
• Essai: ≥98.0% (Total homologs, HPLC)
• Forme: powder
• Solubilité: chloroform: soluble 10 mg/mL
• Spectre d'activité de l'antibiotique: Gram-positive bacteria
• Mode d’action: DNA synthesis | interferes; cell membrane | interferes
• Température de stockage: 2-8°C
• Chaîne SMILES: C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1
• InChI: 1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
• Clé InChI: RMIXHJPMNBXMBU-QIIXEHPYSA-N

Description

Description générale

Chemical structure: macrolide

Application

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation [1].

Actions biochimiques/physiologiques

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, and to inhibit surface expression of certain heat shock proteins (HSP60) [2][3].

Autres remarques

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Gloves, type N95 (US)