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Key Documents

M7820

Sigma-Aldrich

Monoclonal Anti-MAGE-C1 antibody produced in mouse

clone CT7-33, purified from hybridoma cell culture

Synonyme(s) :

Anti-CT7

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

mouse

Conjugué

unconjugated

Forme d'anticorps

purified immunoglobulin

Type de produit anticorps

primary antibodies

Clone

CT7-33, monoclonal

Forme

buffered aqueous solution

Poids mol.

antigen ~180 kDa

Espèces réactives

human

Concentration

~1 mg/mL

Technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
immunoprecipitation (IP): suitable
indirect ELISA: suitable
western blot: 1-2 μg/mL using total cell extract of SKML37 cells

Isotype

IgG1

Numéro d'accès UniProt

Conditions d'expédition

dry ice

Température de stockage

−20°C

Modification post-traductionnelle de la cible

unmodified

Informations sur le gène

human ... MAGEC1(9947)

Description générale

Anti-MAGE-C1 antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the hybridoma CT7-33 produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from mice immunized with human recombinant MAGE-C1. The first melanoma-associated antigen (MAGE) to be identified was MAGE-A1. The MAGE family of proteins contains over 25 genes that have now been identified in human. These proteins share a homologous region, named the MAGE homology domain (MHD).
MAGE family member C1 (MAGE-C1) belongs to the melanoma antigen gene (MAGE) family and consists of 1142 amino acids. The gene encoding MAGE-C1 is localized on human chromosome Xq26-27 and has four exons.

Immunogène

human recombinant MAGE-C1.

Application

  • Anti-MAGE-C1 antibody, Mouse monoclonal has been used in:
  • enzyme-linked immunosorbent assay (ELISA)
  • immunocytochemistry
  • immunoblotting
  • immunoprecipitation
  • immunohistochemistry

Actions biochimiques/physiologiques

Although the physiological role of melanoma-associated antigen (MAGE) proteins is unknown, it has been reported that MAGE-C1 interacts and co-localizes with an additional cancer testis antigen, NY-ESO-1, in melanoma cells.
MAGE family member C1 (MAGE-C1) has been studied as the most expressed cancer or testis antigen in multiple myeloma.

Description de la cible

MAGE-C1 is a member of the melanoma antigen gene (MAGE) family. The proteins of this family are tumor-specific antigens that can be recognized by autologous cytolytic T lymphocytes.

Forme physique

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Code de la classe de stockage

10 - Combustible liquids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificats d'analyse (COA)

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Consulter la Bibliothèque de documents

Kirsty Wienand et al.
PloS one, 10(3), e0120734-e0120734 (2015-03-21)
The malignant cell phenotype of Multiple Myeloma (MM) remains unclear with studies proposing it to be either clonotypic B or proliferating plasma cells. Cancer/testis antigen MAGE C1 is being extensively studied in MM and it has been suggested that it
MAGE-E1, a new member of the melanoma-associated antigen gene family and its expression in human glioma
Sasaki M, et al.
Cancer Research, 61(12), 4809-4814 (2001)
Physical interaction of two cancer-testis antigens, MAGE-C1 (CT7) and NY-ESO-1 (CT6)
Cho HJ, et al.
Cancer Immunity, 6(1), 12-12 (2006)
Achim A Jungbluth et al.
International journal of cancer, 99(6), 839-845 (2002-07-13)
CT7 (MAGE-C1) is a member of the cancer testis (CT) antigen family. The present study describes the generation of CT7-33, a monoclonal antibody (MAb) to CT7, and the preliminary protein expression analysis of CT7 in normal tissues and in a
Henna Mattila et al.
BMC cancer, 11, 327-327 (2011-08-04)
Several predisposition loci for hereditary prostate cancer (HPC) have been suggested, including HPCX1 at Xq27-q28, but due to the complex structure of the region, the susceptibility gene has not yet been identified. In this study, nonsense-mediated mRNA decay (NMD) inhibition

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