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120R-1

Sigma-Aldrich

CD20 (SP32) Rabbit Monoclonal Antibody

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About This Item

Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41

Source biologique

rabbit

Niveau de qualité

100
500

Conjugué

unconjugated

Forme d'anticorps

culture supernatant

Type de produit anticorps

primary antibodies

Clone

SP32, monoclonal

Description

For In Vitro Diagnostic Use in Select Regions (See Chart)

Forme

buffered aqueous solution

Espèces réactives

human

Conditionnement

vial of 0.1 mL concentrate (120R-14)
vial of 0.5 mL concentrate (120R-15)
bottle of 1.0 mL predilute (120R-17)
vial of 1.0 mL concentrate (120R-16)
bottle of 7.0 mL predilute (120R-18)

Fabricant/nom de marque

Cell Marque™

Technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

Isotype

IgG1

Contrôle

tonsil

Conditions d'expédition

wet ice

Température de stockage

2-8°C

Visualisation

membranous

Description générale

Anti-CD20 (pan B-cell) reacts with a membrane antigen that is present in B-cells as this epitope is acquired late in the pre-B-cell stage of maturation and remains on cells throughout most of the differentiation process, although it is lost at the plasma cell stage. This antibody recognizes Reed-Sternberg cells, predominant in classic Hodgkin′s disease, in approximately 20% of cases, and approximately half of lymphoblastic lymphoma/leukemias. Since no staining of histiocytes or plasma cells has been observed and CD20 has rarely been detected in T-cell malignancies, it is a dependable marker of B-cell lymphomas. Anti-CD20 does not cross-react with non-hematopoetic neoplasms.

Liaison

CD20 Positive Control Slides, Product No. 120S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Forme physique

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Notes préparatoires

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Autres remarques

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Informations légales

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Code de la classe de stockage

12 - Non Combustible Liquids

Classe de danger pour l'eau (WGK)

WGK 2

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Diagnostic Immunohistochemistry: Theranostic and Genomic Applications (2006)
G S Pinkus et al.
The American journal of pathology, 133(2), 211-217 (1988-11-01)
Immunoreactivity for L26, a highly effective pan B cell marker that can be detected in paraffin sections, was evaluated in 72 cases of Hodgkin's disease of various histologic types. In all cases of nodular lymphocyte predominance type of Hodgkin's disease
P Korkolopoulou et al.
Histopathology, 24(6), 511-515 (1994-06-01)
Recent evidence indicates that membrane-bound immunoglobulin on B lymphocytes is associated with a molecule which comprises the products of the mb-1 and B29 genes. This molecule is a highly specific marker for B-cells, presumably because of its central functional role
R J Marder et al.
Laboratory investigation; a journal of technical methods and pathology, 52(5), 497-504 (1985-05-01)
Monoclonal antibodies (MoAbs) to B cell- and T cell-specific antigens uniformly have been restricted in their use to cell suspension or frozen section techniques because the antigens that they identify are either masked or lost in the fixation or paraffin-embedding
A L Epstein et al.
Journal of immunology (Baltimore, Md. : 1950), 133(2), 1028-1036 (1984-08-01)
Two monoclonal antibodies (LN-1, LN-2) reactive with B lymphocytes in B5 formalin-fixed, paraffin-embedded tissue sections have been produced by utilizing cell extracts from pokeweed mitogen-stimulated peripheral blood lymphocytes and diffuse histiocytic lymphoma SU-DHL-4 cells, respectively. Both monoclonal antibodies were initially

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