MABN372

Anti-CLN3 Antibody, Clone 2B8.2

clone 2B8.2, from mouse

• Synonyme(s) : Battenin, Batten disease protein, Protein CLN3
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: mouse
• Niveau de qualité: 100
• Forme d'anticorps: purified immunoglobulin
• Type de produit anticorps: primary antibodies
• Clone: 2B8.2, monoclonal
• Espèces réactives: mouse, human
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Isotype: IgG1κ
• Numéro d'accès NCBI: NP_000077
• Numéro d'accès UniProt: Q13286
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CLN3(1201)

Description

Description générale

CLN3 protein is involved in lysosomal function. Mutations in this, as well as other neuronal ceroid-lipofuscinosis (CLN) genes, cause neurodegenerative diseases commonly known as Batten disease or collectively known as neuronal ceroid lipofuscinoses (NCLs).

Immunogène

KLH-conjugated linear peptide corresponding to human CLN3.

Application

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-CLN3 Antibody, Clone 2B8.2 is validated for use in Western Blotting and Immunohistochemistry for the detection of CLN3.

Western Blotting Analysis: 2.0 µg/mL from a representative lot detected CLN3 in 10 µg of A431 cell lysate.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected CLN3 in rat cerebellum and human thalamus tissue.

Qualité

Evaluated by Western Blotting in HepG2 cell lysate.

Western Blotting Analysis: 2.0 µg/mL of this antibody detected CLN3 in 10 µg of HepG2 cell lysate.

Description de la cible

~45 kDa observed. Uniprot describes 5 isoforms produced by alternative splicing at ~45, ~42, ~37, ~35, and ~28 kDa

Forme physique

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Autres remarques

Concentration: Please refer to lot specific datasheet.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 12 - Non Combustible Liquids
• Classe de danger pour l'eau (WGK): WGK 1
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable