GHRT-89HK

Human Ghrelin (TOTAL) RIA

• Code UNSPSC : 12161503
• eCl@ss : 32161000
• Nomenclature NACRES : NA.84

Propriétés

• Qualité: for protein analysis
• Niveau de qualité: 100
• Description: ED₈₀ = 395 ± 88 pg/mL ED₅₀ = 895 ± 177 pg/mL ED₂₀ = 2015 ± 382 pg/mL ; analytes available: Ghrelin
• Caractéristiques: accuracy 90–96%
• Espèces réactives: human
• Plage de mesure de la sensibilité: 100-10000 pg/mL
• Technique(s): radioimmunoassay: suitable
• Numéro d'accès UniProt: Q9UBU3
• Méthode de détection: radioactive

Description

Description générale

FUNCTION: SwissProt: Q9UBU3 # Obestatin may be the ligand for GPR39. May have an appetite-reducing effect resulting in decreased food intake. May reduce gastric emptying activity and jejunal motility (By similarity).
SIZE: 117 amino acids; 12911 Da
SUBCELLULAR LOCATION: Secreted.
TISSUE SPECIFICITY: Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.
PTM: O-octanoylation or O-decanoylation is essential for ghrelin activity. The O-decanoylated forms Ghrelin-27-C10 and Ghrelin-28- C10 differ in the length of the carbon backbone of the carboxylic acid bound to Ser-26. A small fraction of ghrelin, ghrelin-28- C10:1, may be modified with a singly unsaturated carboxylic acid. & Amidation of Leu-98 is essential for obestatin activity (By similarity).
SIMILARITY: SwissProt: Q9UBU3 ## Belongs to the motilin family.

Application

Two-day disequilibrium assay at 4°C. Sample volume: ≤ 100 μL Plasma (collected on ice) recommended

Remarque sur l'analyse

Linearity 99–146%

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Pictogrammes: GHS02,GHS06,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H226,H302 + H332,H311,H319,H336,H411
• Conseils de prudence: P210 - P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P312
• Classification des risques: Acute Tox. 3 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Flam. Liq. 3 - STOT SE 3
• Organes cibles: Central nervous system
• Code de la classe de stockage: 3 - Flammable liquids