ABN494

Anti-PHOX2A Antibody

from rabbit, purified by affinity chromatography

• Synonyme(s) : Paired-like homeobox 2A, Paired mesoderm homeobox protein 2A
• Code UNSPSC : 12352203
• eCl@ss : 32160702
• Nomenclature NACRES : NA.41

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Forme d'anticorps: affinity isolated antibody
• Type de produit anticorps: primary antibodies
• Clone: polyclonal
• Produit purifié par: affinity chromatography
• Espèces réactives: human, rat
• Technique(s): immunohistochemistry: suitable; western blot: suitable
• Numéro d'accès UniProt: O14813
• Conditions d'expédition: wet ice
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... PHOX2A(401)

Description

Description générale

Paired mesoderm homeobox protein 2A (PHOX2A), also known as ARIX1 homeodomain protein (ARIX) and Paired-like homeobox 2A (PMX2A), along with the closely related PHOX2B, is a paired-homeodomain transcription factor that maintains the noradrenergic phenotype during embryogenesis. PHOX2 proteins help regulate endogenous hydroxylases in neural crest cells and aid in sympathetic neuron generation. PHOX2A controls only the differentiation of the main noradrenergic center of the human brain, while PHOX2B is required for the differentiation of all central and nonperipheral noradrenergic centers. PHOX2A may be involved in regulating specific expression of catecholamine biosynthetic genes. PHOX2A is linked to congenital fibrosis of extraocular muscles type 2 (CFEOM2). PHOX2 regulation may have therapeutic applications for aging or degenerative noradrenergic neuron disorders.

Immunogène

KLH-conjugated linear peptide corresponding to human PHOX2A.

Application

Anti-PHOX2A Antibody is a highly specific rabbit polyclonal antibody, that targets Phox2a & has been tested in western blotting & IHC.

Immunohistochemistry Analysis: 2.5 µg/mL from a representative lot detected PHOX2A in human brain tissue.

Research Category
Neuroscience

Research Sub Category
Neurodegenerative Diseases

Qualité

Evaluated by Western Blotting/Peptide Inhibition Assay in rat brain tissue lysate.

Western Blotting/Peptide Inhibition Assay Analysis: 1µg/mL of this antibody detected PHOX2A in 15 µg of rat brain tissue lysate.

Description de la cible

~32 kDa observed. Uncharacterized bands may appear in some lysate(s).

Forme physique

Antigen Affinity Purified

Purified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.

Stockage et stabilité

Stable for 1 year at 2-8°C from date of receipt.

Remarque sur l'analyse

Control
Rat brain tissue lysate

Autres remarques

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Clause de non-responsabilité

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable